Xiao T Sam TS - OmicsDI

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Conversion of Fibroblasts into Functional Trophoblast Stem-like Cells

Here we demonstrate the generation of stable induced trophoblast stem cells (iTSCs) from fibroblasts by the transient expression of Gata3, Eomes and Tfap2c. Transcriptome and methylome analyses and functional assays such as hemorrhagic lesion formation and placenta contribution suggested a high deg...

ORGANISM(S): Mus musculus

2016-07-05 | E-GEOD-70234 | biostudies-arrayexpress

Transcriptional profiling of p56lck-deficient regulatory and memory T cells

Signaling through the T cell antigen receptor is essential for the formation of regulatory T (Treg) cells in the thymus and for their involvement in antigen-directed suppression of immune responses. Using a conditional null allele of the gene encoding p56Lck we show here that T cell antigen recepto...

ORGANISM(S): Mus musculus

2010-05-22 | E-GEOD-13645 | biostudies-arrayexpress

H2A.X native ChIP-Seq in TSC; Histone Variant H2A.X Mediated Epigenetic Mechanisms are Critical for Pluripotency in ES and iPS Cells

With the advent of the induced pluripotent stem cell (iPSC) technology, how to distinguish the developmental potentials of the iPSC clones with molecular approaches becomes an imperative issue. Herein, we demonstrated that histone variant H2A.X plays an unexpected role in distinguishing the develop...

ORGANISM(S): Mus musculus

2014-09-07 | E-GEOD-57216 | biostudies-arrayexpress

Quantifying the fatal and non-fatal burden of disease associated with child growth failure, 2000-2023: a systematic analysis from the Global Burden of Disease Study 2023.

Not available

S-EPMC12674951 | biostudies-literature

Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023.

Not available

S-EPMC12535839 | biostudies-literature

Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.

Not available

S-EPMC12535838 | biostudies-literature

Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.