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MetabolomicsXiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights
TranscriptomicsChromatin immunoprecipitation of three PcG proteins and of histone H3 trimethylated at Lys 27 in Drosophila
We determined the distribution of three PcG proteins: PC, PSC and E(Z), and of histone H3 trimethylated at Lys 27 by chromatin immunoprecipitation (ChIP) coupled with analysis of immunoprecipitated DNA with a high density genomic tiling microarray (Affymetrix).
ORGANISM(S): Drosophila melanogaster 
2006-12-30 | E-MEXP-535 | biostudies-arrayexpress
UnknownHuman genomic Z-DNA segments probed by the Z alpha domain of ADAR1.
Not available
S-EPMC2677879 | biostudies-literature
Unknown2'-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA.
Not available
S-EPMC6222775 | biostudies-literature
UnknownResearch on multi-objective optimization method of Z-shaped pipeline structure based on Kriging model.
Not available
S-EPMC11604928 | biostudies-literature
UnknownInfluence of FtsZ GTPase activity and concentration on nanoscale Z-ring structure in vivo revealed by three-dimensional Superresolution imaging.
Not available
S-EPMC4958570 | biostudies-literature
TranscriptomicsTranscription profiling of 8-day-old Podocin-Cre, Z/EG double transgenic mice glomerulus and brain
Mouse glomeruli and brain capillary fragments were prepared. Podocytes were separated from isolated glomeruli from 8-day-old Podocin-Cre, Z/EG double transgenic mice as follows: Isolated glomeruli were incubated with trypsin solution containing 0.2 % trypsin-EDTA (Sigma-Aldrich), 100ug/ml Heparin an...
ORGANISM(S): Mus musculus 
2006-10-31 | E-MEXP-492 | biostudies-arrayexpress
UnknownA conserved coiled-coil protein pair focuses the cytokinetic Z-ring in Caulobacter crescentus.
Not available
S-EPMC5570653 | biostudies-literature
UnknownIn vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury.
Not available
S-EPMC11579379 | biostudies-literature
UnknownRAS, a Pentatricopeptide Repeat Protein, Interacts with OsTRX z to Regulate Chloroplast Gene Transcription and RNA Processing.
Not available
S-EPMC11768195 | biostudies-literature
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