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MetabolomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis

Background: Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host...

2026-02-25 | MTBLS13930 | MetaboLights
TranscriptomicsTNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP
The pediatric immune deficiency X-linked proliferative disease-2 (XLP-2) is a unique disease, with patients presenting with either hemophagocytic lymphohistiocytosis (HLH) or intestinal bowel disease (IBD). Interestingly, XLP-2 patients display high levels of IL-18 in the serum even while in stable ...
ORGANISM(S): Mus musculus 
2021-03-01 | E-MTAB-10103 | biostudies-arrayexpress
ProteomicsXIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1
X-linked inhibitor of apoptosis protein (XIAP), a member of the IAP family, is overexpressed in a variety of tumors and plays an important role in tumor progression. Increasing evidence suggests that XIAP promotes metastasis of bladder cancer but the underlying mechanism is not very clear. The RNA N...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055868 | Pride
Bladder cancer invasion/ubiquitylation/xiap/ythdc1/mmp-2 
TranscriptomicsStable XIAP knockdown in HCT116 colon cancer cells
X-linked inhibitor of apoptosis (XIAP) is the most potent endogenous caspase inhibitor preventing cell death via caspase-9, -7 and -3 (initiator and executioner caspase pathways). Using short hairpin RNA (shRNA) against XIAP, stably expressed in a parent HCT116 human colon cancer cell line, a series...
ORGANISM(S): Homo sapiens 
2008-12-01 | GSE11618 | GEO
ProteomicsGoncharov et al. Raw data files
Raw KGG ubiquitination MS data files for two biological replicate studies of Nod2 receptor activation +/- XIAP inhibition.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-03 | MSV000081881 | MassIVE
GenomicsExpression profile of cells overexpressing genetic variants encoding XIAP with distinct subcellular localization.
Expression profile of cells overexpressing genetic variants encoding XIAP with distinct subcellular localization.
PRJNA1266207 | ENA
TranscriptomicsTNFa-stimulation of XIAP -/- MEF
XIAP (X chromosome-linked inhibitor of apoptosis; ILP, BIRC4) is involved not only in apoptosis, but also in signal tranduction in the NF-kappaB, TGF-beta, bone morphogenic protein, and JNK signalling pathways. We have analyzed whether XIAP deletion leads to changes in gene expression, particularly ...
ORGANISM(S): Mus musculus 
2008-11-12 | GSE3700 | GEO
GenomicsEBV infection in XIAP patients
Epstein Barr virus-mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1
PRJEB56290 | ENA
GenomicsEBV infection in XIAP patients
Epstein Barr virus mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1
PRJEB57726 | ENA
GenomicsRNAseq of pedriatic IBD and XIAP-deficient biopsy samples
RNAseq of pedriatic IBD and XIAP-deficient biopsy samples
PRJNA759006 | ENA
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