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MetabolomicsMetabolomic approaches to dissect dysregulated metabolism in the progression of pre-diabetes to T2DM

Most of pre-diabetes were eventually progress to diabetes, thereby profiling of prediabetic metabolic disorders may be an effective targeted preventive measure. We aimed to elucidate internal motivation of the progression of pre-diabetes to type 2 diabetes mellitus (T2DM) from a metabolic perspec...

2024-04-29 | MTBLS8644 | MetaboLights
TranscriptomicsTranscription profiling of human hematopoietic stem cells
Successful ex vivo expansion of hematopoietic stem cells (HSCs) would greatly benefit the treatment of disease and the understanding of critical questions of stem cell biology. Microarray studies showed that the HSC supportive mouse fetal liver CD3+ cells specifically expressed angiopoietin-like 2 (...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3609 | biostudies-arrayexpress
UnknownSubcutaneous Construction of Engineered Adipose Tissue with Fat Lobule-Like Structure Using Injectable Poly-Benzyl-L-Glutamate Microspheres Loaded with Adipose-Derived Stem Cells.
Not available
S-EPMC4537260 | biostudies-literature
UnknownTransforming L1000 profiles to RNA-seq-like profiles with deep learning.
Not available
S-EPMC9472394 | biostudies-literature
TranscriptomicsMicroRNA analysis unravels the molecular basis of bleomycin induced lung fibrosis in mouse
The molecular mechanisms of lung injury and fibrosis are incompletely understood. microRNAs (miRNAs) are crucial biological regulators by suppression of their target genes and are involved in a variety of pathophysiologic processes. To gain insight into miRNAs in the regulation of lung fibrosis, tot...
ORGANISM(S): Mus musculus 
2012-04-12 | E-GEOD-24323 | biostudies-arrayexpress
UnknownDuplication and diversification of lectin receptor-like kinases (LecRLK) genes in soybean.
Not available
S-EPMC5897391 | biostudies-literature
TranscriptomicsResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
We explored potential bypass mechanisms to PI3K/mTOR-directed therapy in KRAS mutant CRC models, utilizing genetically engineered mouse models (GEMM) to generate acquired resistance to the targeted dual PI3K/mTOR small molecule inhibitor PF-04691502. Transcriptomic analysis revealed a dynamic stem-l...
ORGANISM(S): Mus musculus 
2014-08-31 | E-MTAB-2510 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of murine GIST-like tumors after Etv1 ablation
We used a mouse expressing three alleles 1) KitV558Delta/+ activating allele that develop GIST-like tumors in the cecum, 2) Etv1 flox/flox conditional knockout allele and 3) Rosa26-CreERT2 tamoxifen activated Cre allele. Mice were treated with either Tamoxifen (to delete Etv1) or corn oil (control)....
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-64608 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of salt stress responsiveness in the seedlings of Dongxiang wild rice (Oryza rufipogon Griff.)
Dongxiang wild rice (Oryza rufipogon Griff.) is the progenitor of cultivated rice (Oryza sativa L.) and is well known for its superior level of tolerance against cold, drought and diseases. To date, however, little is known about the salt-tolerant character of Dongxiang wild rice. To elucidate the m...
ORGANISM(S): Oryza rufipogon 
2016-01-13 | E-GEOD-73181 | biostudies-arrayexpress
UnknownMultilevel Differential Control of Hormone Gene Expression Programs by hnRNP L and LL in Pituitary Cells.
Not available
S-EPMC5974433 | biostudies-literature
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