Xie Wenjie W - OmicsDI

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Proteomics (1)
Metabolomics (1)

Organisms

Homo sapiens (1)
Mus musculus (1)

Repository

iProX (1)
MetaboLights (1)

Technology Type

Mass spectrometry (1)

Instrument Platform

Liquid Chromatography MS - negative - reverse phase (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2023 (1)

CHEBI ID

CHEBI:190663 (1)
CHEBI:164781 (1)
CHEBI:159767 (1)
CHEBI:194292 (1)
CHEBI:161812 (1)
CHEBI:158783 (1)
CHEBI:194290 (1)
CHEBI:194289 (1)
CHEBI:194284 (1)
CHEBI:194280 (1)
CHEBI:161337 (1)
CHEBI:194276 (1)
CHEBI:194264 (1)
CHEBI:68747 (1)
CHEBI:194277 (1)
CHEBI:194271 (1)
CHEBI:190673 (1)
CHEBI:194262 (1)
CHEBI:194255 (1)
CHEBI:194251 (1)
CHEBI:194267 (1)
CHEBI:194288 (1)
CHEBI:194266 (1)
CHEBI:194252 (1)
CHEBI:131660 (1)
CHEBI:183722 (1)
CHEBI:183464 (1)
CHEBI:114276 (1)
CHEBI:160058 (1)
CHEBI:194256 (1)

Metabolite Name

ACar 24:2 (1)
4-(3-methyl-1-phenyl-1H-pyrazolo[3,4-b]quinolin-4-yl)morpholine (1)
LysoPC 16:2 (2N Isomer) (1)
Ethyl 4-amino-2-[(3-nitro-2-pyridyl)thio]pyrimidine-5-carboxylate (1)
N-(4-fluorophenyl)-N'-[2-methyl-5-(piperidinosulfonyl)-3-furyl]urea (1)
2-[2-oxo-2-(pyridin-3-ylamino)ethoxy]acetic acid (1)
N-(4-chlorophenyl)-5-hex-1-ynylnicotinamide (1)
Methyl 6-[(4-chlorophenyl)thio]-5-nitronicotinate (1)
PC (20:1/20:2) (1)
-Estradiol (1)
4-(2-furyl)-2-oxo-6-(2-thienyl)-1,2-dihydro-3-pyridinecarbonitrile (1)
-Aspartylphenylalanine (1)
L-Glutathione (oxidized) (1)
-Glutamylcysteine (1)
11,12-DiHETE (1)
2-({2-[(5-methylisoxazol-3-yl)amino]-2-oxoethyl}thio)acetic acid (1)
NPK (1)
(S)-Bromoenol lactone (1)
PE (18:1/18:2) (1)
Alpha-Lapachone (1)
2-(4-hydroxy-1,3-thiazol-2-yl)-1-phenylethan-1-one (1)
PE (17:1/17:1) (1)
ACar 22:1 (1)
LysoPC 20:0 (1)
Evernic acid (1)
N4-(4-chloro-2,5-dimethoxyphenyl)morpholine-4-carbothioamide (1)
3-(allylsulfanyl)-4-[4-(benzyloxy)phenyl]-5-methyl-4H-1,2,4-triazole (1)
2-[(5-anilino-4-phenyl-4H-1,2,4-triazol-3-yl)thio]acetic acid (1)
TLK (1)
PC (15:0/16:1) (1)

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Lysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals

We report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenou...

ORGANISM(S): Homo Sapiens Mus Musculus

Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness

The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...

2023-01-17 | MTBLS6661 | MetaboLights

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