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TranscriptomicsLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that bi-allelic inactivation of Lkb1 and Pten in the mouse lung led to SCC that recapitulated the histology, gene expression and microenvironment found in human disease. Lkb1/Pten-null ...
ORGANISM(S): Mus musculus 
2014-01-24 | E-GEOD-54351 | biostudies-arrayexpress
TranscriptomicsLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-01-24 | E-GEOD-54353 | biostudies-arrayexpress
TranscriptomicsLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Stroma Cells
Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that bi-allelic inactivation of Lkb1 and Pten in the mouse lung led to SCC that recapitulated the histology, gene expression and microenvironment found in human disease. Lkb1/Pten-null ...
ORGANISM(S): Mus musculus 
2014-01-24 | E-GEOD-54352 | biostudies-arrayexpress
TranscriptomicsNSCLC Driven by DDR2 Mutation is Sensitive to JQ1 and Dasatinib Combination Therapy
Genetically engineered mouse models of lung cancer have demonstrated an important role in understanding the function of novel lung cancer oncogenes and tumor suppressor genes identified in genomic studies of human lung cancer. Further, these models are important platforms for pre-clinical therapeuti...
ORGANISM(S): Mus musculus 
2015-01-14 | E-GEOD-64907 | biostudies-arrayexpress
ProteomicsMulti-omic Profiling of Plasma Identify Biomarkers and Pathogenesis of COVID-19 in Children
Although people of all ages are susceptible to COVID-19, children usually develop less severe disease than adults. Little is known about the pathogenesis of COVID-19 in children. Herein, we conduct the plasma proteomic and metabolomic profiling of a cohort of COVID-19 children patients with mild sym...
ORGANISM(S): Homo Sapiens 
2021-06-28 | PXD026962 |
ProteomicsHuman colon cancer HCT116 cell LC/MSMS
Mitosis deregulation is a key event during carcinogenesis. Alternative splicing spectrum alteration plays a critical role during mitosis shift. However, the molecules responsible for dysregulated alternative splicing driving carcinogenetic mitosis remain poorly defined. Here, we demonstrate that can...
ORGANISM(S): Homo Sapiens 
PXD018242 |
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