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GenomicsIdentification of the primary target of the chemotherapeutic agent CX-5461 as a late step in transcription initiation by RNA Polymerase I
In recent years, several small molecule cytotoxic drugs have been identified as potential inhibitors of ribosome biogenesis (Drygin et al., 2011; Peltonen et al., 2014a; Peltonen et al., 2014b). CX-5461 is one such drug that has also demonstrated anticancer potential for a wide range of malignancies...
ORGANISM(S): Mus musculus 
2021-04-07 | E-MTAB-9242 | biostudies-arrayexpress
UnknownSuper-resolution imaging of live sperm reveals dynamic changes of the actin cytoskeleton during acrosomal exocytosis.
Not available
S-EPMC6240301 | biostudies-literature
UnknownSingle-Cell and Time-Resolved Profiling of Intracellular Salmonella Metabolism in Primary Human Cells.
Not available
S-EPMC7006958 | biostudies-literature
UnknownBiological and Genomic Insights into <i>Fusarium acuminatum</i> Causing Needle Blight in <i>Pinus tabuliformis</i>.
Not available
S-EPMC12470730 | biostudies-literature
UnknownEvidence for an intracellular localization of the adenosine A2B receptor in rat cardiomyocytes.
Not available
S-EPMC3533442 | biostudies-literature
ProteomicsTRAJECTORY ANALYSIS OF HEPATIC STELLATE CELL DIFFERENTIATION REVEALS METABOLIC REGULATION OF CELL COMMITMENT AND FIBROSIS
Defining the trajectory of cells during differentiation and disease is key for uncovering the mechanisms driving cell fate and identity. However, trajectories of human cells remain largely unexplored due to the challenges of studying them with human samples. In this study, we investigated the proteo...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058290 | Pride
Ipscs Dihscs Rora Metabolic plasticity 
UnknownRecombination Suppression Drives Expansion of the Drosophila Dot Chromosome.
Not available
S-EPMC12728734 | biostudies-literature
TranscriptomicsIntratumor heterogeneity of gene expression profiles in early stage non-small cell lung cancer (NSCLC)
Gene expression profiling of NSCLC tissues let to the establishment of several prognostic, predictive gene signatures with little overlap. To study factors introducing variability into gene expression microarray studies we compared interpatient (patient-to-patient) and intrapatient (tumor sub-sample...
ORGANISM(S): Homo sapiens 
2014-09-23 | E-GEOD-33532 | biostudies-arrayexpress
UnknownInfertility and incident endometrial cancer risk: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2).
Not available
S-EPMC4453954 | biostudies-literature
UnknownIntrauterine devices and endometrial cancer risk: a pooled analysis of the Epidemiology of Endometrial Cancer Consortium.
Not available
S-EPMC4267918 | biostudies-literature
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