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GenomicsTELP, a sensitive and versatile library construction method for next-generation sequencing
Next-generation sequencing has been widely used for the genome-wide profiling of histone modifications, transcription factor binding and gene expression through chromatin immunoprecipitated DNA sequencing (ChIP-seq) and cDNA sequencing (RNA-seq). Here, we describe a versatile library construction me...
ORGANISM(S): Mus musculus 
2015-12-15 | E-GEOD-75966 | biostudies-arrayexpress
UnknownFlavin Containing Monooxygenase 2 Prevents Cardiac Fibrosis via CYP2J3-SMURF2 Axis.
Not available
S-EPMC9932658 | biostudies-literature
ProteomicsUSP5 Stabilizes YTHDF1 to Control Cancer Immune Surveillance through mTORC1-mediated Phosphorylation
The N6-methyladenosine (m6A) binding protein YTHDF1 emerges as a frequently upregulated oncogene across various cancer types. Its depletion significantly improves the efficacy of cancer immune checkpoint blockade (ICB) treatment. A comprehensive understanding of the molecular mechanisms governing YT...
ORGANISM(S): Homo Sapiens 
2024-11-14 | PXD057917 |
ProteomicsOTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR
To explore the underlying mechanism by which OTUD6A induces PCa progression, we identified its binding proteins with an immunoprecipitation (IP)-mass spectrometry (MS) approach in two CRPC cell lines.
ORGANISM(S): Homo Sapiens 
2022-01-28 | PXD031307 |
ProteomicsIdentification of TRADD phosphorylation sites
We re-introduced Flag-mTRADD into Tradd-/- MEFs, and identified the phosphorylation sites of TRADD which were induced by TNF and inhibited by TAK1 inhibitor 5Z7 using mass spectrometry. We found that TAK1 could mediate the phosphorylation of multiple sites in TRADD upon TNF stimulation. We next perf...
ORGANISM(S): Homo Sapiens 
PXD056588 |
ProteomicsArrestin engagement of the metabotropic glutamate receptor mGlu5
Phosphorylation sites identified at the C-terminus of mGlu5 by mass spectrometry analysis
ORGANISM(S): Homo Sapiens 
PXD076479 |
ProteomicsMechanistic Insight into Glioma Through Spatially Multidimensional Proteomics
Characterizing the tumor microenvironment at the molecular level is essential for understanding the mechanisms of tumorigenesis and evolution. However, the specificity of the blood proteome in localized region of the tumor and its linkages with other systems is difficult to investigate. Here, we pro...
ORGANISM(S): Homo Sapiens 
PXD043970 |
Proteomicsthe function of RNA Binding Protrein in cancer
RNA Binding Protrein plays of vital imortance in cancer progression.
ORGANISM(S): Homo Sapiens 
2021-12-08 | PXD022776 |
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