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TranscriptomicsArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
RELEVANCE: Smith-Lemli-Opitz syndrome (SLOS) is a human disease caused by mutations in the gene coding for the enzyme DHCR7 (7-dehydrocholesterol (7DHC) reductase), which catalyzes the final step of cholesterol biosynthesis. Accumulated 7DHC in tissues and body fluids of SLOS patients gives rise t...
ORGANISM(S): Mus musculus 
2021-03-20 | E-MTAB-10055 | biostudies-arrayexpress
GenomicsH3K27me3 in human bladder transitional cell carcinoma cell line CL1207
The H3K27me3 ChIP-seq data for the human bladder transitional cell carcinoma cell line CL1207 were generated in order to detect regions of regional epigenetic silencing in this cell line and test the performance of several peak calling tools: CCAT (Xu et al., 2010) and HMCan (Ashoor et al., "HM...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-44438 | biostudies-arrayexpress
TranscriptomicsTreatment of MM cells with IMiDs or reducing the expression of EIF2C2 significantly affects steady-state levels of miRNAs
Lenalidomide is a therapeutically active compound that binds to E3 ubiquitin ligase recruiter cereblon (CRBN) and induces cytotoxicity. We have identified eukaryotic translation initiation factor 2 subunit C2 (EIF2C2) as a new member of CRBN-downstream binding protein that plays an important role in...
ORGANISM(S): Homo sapiens 
2016-03-09 | E-GEOD-61693 | biostudies-arrayexpress
MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
UnknownTwo kinds of rare light chain cast nephropathy caused by multiple myeloma: case reports and literature review.
Not available
S-EPMC7845023 | biostudies-literature
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
TranscriptomicsComparative profiling of human fetal and adult erythropoiesis
This SuperSeries is composed of the following subset Series: GSE36984: Expression Profiling of Primary Human Fetal and Adult Hematopoietic Stem/Progenitor Cells (HSPCs) and Differentiating Proerythroblasts (ProEs) GSE36985: Comparative profiling of chromatin state maps and transcription factor occup...
ORGANISM(S): Homo sapiens 
2012-10-04 | E-GEOD-36994 | biostudies-arrayexpress
UnknownVisual impairment as the initial presentation in multiple myeloma: a case report and literature review.
Not available
S-EPMC11483438 | biostudies-literature
MetabolomicsSerum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy
Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying therapies is essential to reduce inflammation and prevent destruction of the joint. RA is a heterogeneous disease,...
2025-08-14 | MTBLS6213 | MetaboLights
GenomicsComparative profiling of chromatin state maps and transcription factor occupancy during human fetal and adult erythropoiesis
We report the comparative investigation of genome-wide chromatin state maps, transcription factor (TF) occupancy, and gene expression profiles from developing red cell precursors at two developmental stages. Contrasting the similarities and differences between fetal and adult erythropoiesis provides...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-36985 | biostudies-arrayexpress
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