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MetabolomicsPTER is an N-acetyltaurine hydrolase that regulates feeding and obesity

Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans1-3. In endogenous taurine metabolism, dedicated enzymes are involved in biosynthesis of taurine from cysteine as well as the downstream metabolism of secondary taurine metabolites4,5. One such ta...

2024-09-11 | MTBLS10408 | MetaboLights
ProteomicsTransketolase promotes MAFLD by limiting inosine-induced mitochondrial activity (Proteomics)
Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse M...
ORGANISM(S): Homo Sapiens 
2024-02-26 | PXD050130 |
TranscriptomicsPatch-seq Sequencing of mouse glioma cells
Mouse glioma cells are recorded through patch-seq first, and the cytosol was collected afterwards, and the whole transcriptomic RNA library was reconstructed and sequenced afterwards.
ORGANISM(S): Mus musculus 
2026-05-31 | E-MTAB-17027 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of Pseudomonas protegens Pf-5 treated with pyoluteorin and ΔphlG strain
To acquired insights into the pyoluteorin-mediated physiological process of P. fluorescens, label-free quantitative proteomics was used to compare the expression differences between the whole proteome of Pf-5 with and without pyoluteorin. To further investigate the importance of PhlG in physiologica...
ORGANISM(S): Pseudomonas Protegens Pf-5 
2023-01-09 | PXD039317 |
ProteomicsSerum proteomics of T2DM individuals with HFpEF after dapagliflozin treatment by tandem mass spectrometry
A quantitative proteomic profiling by TMT was performed on serum of T2DM individuals with or without dapagliflozin treatment
ORGANISM(S): Homo Sapiens 
2022-10-18 | PXD037538 |
ProteomicsProteomic Profiling Reveals Indicative Biomarkers for Diabetic Retinopathy with Diabetic Kidney Disease
Diabetes retinopathy (DR) and diabetes kidney disease (DKD) are the complications of diabetes and causing serious health and economic burden to society. However, identification and characterization of early biomarkers for DKD, especially for non-proliferative DR (NPDR) patients with DKD, are still l...
ORGANISM(S): Homo Sapiens 
2022-08-19 | PXD036172 |
ProteomicsMolecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules
The production of secondary metabolites is one of the major mechanisms for beneficial rhizobacteria to antagonize plant pathogens. However, simultaneously producing large quantities of different secondary metabolites can pose great metabolic burdens and exerts a significant fitness cost on the produ...
ORGANISM(S): Pseudomonas Fluorescens F113 
2021-04-15 | PXD025403 |
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