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ProteomicsEXoO-Tn: Tag-n-Map the Tn Antigen in the Human Proteome
Tn antigen (Tn), a single N-acetylgalactosamine (GalNAc) monosaccharide attached to protein Ser and Thr residues, is found on most solid tumors yet rarely detected in adult tissues: featuring it one of the most distinctive signatures of cancers. Although it is prevalent in cancers, Tn-glycosylation ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD014390 | Pride
Tn antigen Glycoproteomics O-galnac Exoo-tn 
ProteomicsSite-specific Extraction of O-linked glycopeptides (EXoO) Maps Landscape of In Vivo O-linked Glycoproteome
Protein glycosylation is one of the most common protein modifications and plays essential roles in biology and therapeutics. However, the analysis of in vivo O-linked glycosylation, a major type of protein glycosylation, has been severely impeded by the scarcity of technology. Here, a chemoenzymatic...
ORGANISM(S): Homo sapiens (Human) 
2018-12-05 | PXD009476 | Pride
Site-specific Glycosylation Exoo In vivo O-linked 
ProteomicsProteomic and transcriptome analysis of DIA protein in Morchella edulis
In proteomics, DIA technology, as a high-throughput and high-sensitivity protein detection technique, can comprehensively and accurately identify and quantify proteins in samples. For morel mushrooms, DIA proteomic analysis can provide a deeper understanding of their protein composition, structure, ...
ORGANISM(S): Morchella Sextelata 
2024-11-25 | PXD058217 |
ProteomicsMulti-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy
Cellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D+Q) has shown promise in mitigating age-related pathologies, its long-term effects and underlying mu...
ORGANISM(S): Homo Sapiens 
2026-03-24 | PXD076057 |
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