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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
TranscriptomicsReal-time quantitative PCR analysis of microRNAs in human PBMC samples
A significant percentage of HIV-infected individuals experience a sharp decline in CD4+ T cell counts and progress to AIDS quickly after primary infection. Identification of biomarkers distinguishing rapid progressors (RPs) versus chronic progressors (CPs) is critical for early clinical intervention...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-44332 | biostudies-arrayexpress
ProteomicsProteome of Chinese Breast Cancers (FUSCC-Shao Lab)
Raw data of TMT-labeled proteome of Chinese breast cancers. Uploaded by Zhi-Ming Shao Lab, Fudan University Shanghai Cancer Center (FUSCC)
ORGANISM(S): Homo Sapiens 
PXD042886 |
UnknownUltrahigh-energy gamma-ray emission associated with black hole-jet systems.
Not available
S-EPMC12746838 | biostudies-literature
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