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MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
UnknownU1 snRNP regulates chromatin retention of noncoding RNAs.
Not available
S-EPMC12018070 | biostudies-literature
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
ProteomicsAberrant NAD+ metabolism underlies Zika virus-induced microcephaly
ZIKV-infection during pregnancy can cause microcephaly in newborns, yet the underlying mechanisms remain largely unexplored. Here, we reveal extensive and large-scale metabolic reprogramming events in ZIKV-infected mouse brains. We perform a multi-omics study comprising transcriptomics, proteomics, ...
ORGANISM(S): Mus Musculus 
2021-06-18 | PXD026814 |
ProteomicsUBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation
Osteosarcoma (OS) responds poorly to immune-checkpoint blockade (ICB), and the molecular drivers of its immune-cold state remain unclear. Using multi-omics analyses, we identified an immune-cold OS subtype characterized by enrichment of protein SUMOylation and found the SUMO E1 subunit UBA2 as a key...
ORGANISM(S): Homo Sapiens 
2026-01-28 | PXD073700 |
ProteomicsPRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub
A major challenge to the current efforts to cure HIV-1 infection is the persistence of latent viruses. Addressing this challenge hinges on unraveling the intricate interplay between the host and viral factors that are key for HIV-1 latency. Current antiretroviral agents effectively prevent actively ...
ORGANISM(S): Homo Sapiens 
2025-03-25 | PXD062187 |
ProteomicsIntegrative proteomic characterization of human lung adenocarcinoma
Genomic studies of lung adenocarcinoma (LUAD) have advanced understanding of the disease’s biology and accelerated targeted therapy. However, proteomic characteristics of LUAD remain poorly understood. We carried out comprehensive proteomic analysis of 103 cases of LUAD in Chinese patients. Integrat...
ORGANISM(S): Homo Sapiens 
2020-07-10 | PXD020252 |
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