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MetabolomicsThe glycosyltransferase UGT76B1 modulates N-hydroxy-pipecolic acid homeostasis and plant immunity
The trade-off between growth and defense is a critical aspect of plant immunity. Therefore, the plant immune response needs to be tightly regulated. Salicylic acid (SA) is an important plant hormone regulating defense against biotrophic pathogens. Recently, N-hydroxy-pipecolic acid (NHP) was identif...
2022-02-28 | MTBLS2334 | MetaboLights
GenomicsNUP98-PHF23
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-54788 | biostudies-arrayexpress
GenomicsGenome wide localization of chromatin bound NUP98-PHF23 (NP23)
We analyzed the genome wide localization of H3K4me3, H3K27me3 and the NUP98-PHF23 (with V5 tag) fusion protein which binds H3K4me3 via its PHD finger, using ChIP-seq. Results correlated with gene expression profiles. NUP98-PHF23 bound only 1.6% of H3K4me3 marks including Hoxa/b + Meis1. Assess H3K4m...
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-54786 | biostudies-arrayexpress
TranscriptomicsGene expression study of leukemic and premalignant hematopoietic tissues from NUP98-PHF23 (NP23) mice.
NUP98-PHF23 is oncogenic and results in a Hoxa/b + Meis1 overexpression in NP23 leukemias and in premalignant (clinically healthy) hematopoietic tissues. Gene expression profiles from AML, pre-T LBL and B-ALL were compared to wild type bone marrow, thymus and spleen tissues respectively. Similarly, ...
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-54787 | biostudies-arrayexpress
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