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TranscriptomicsFunctional and Transcriptomic Characterization of iPSC-derived Macrophages and their Application in Modeling Mendelian Disease
Using RNA-Seq, we reported novel findings in the comparison of transcriptome profiles of isogenic HMDM and IPSDM during differentiation and polarization. First, IPSDM lost expression of pluripotency markers, had remarkably distinct gene expression profiles relative to precursor iPSCs, and had largel...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-GEOD-55536 | biostudies-arrayexpress
TranscriptomicsEvaluating the Impact of Sequencing Depth on Transcriptome Profiling in Human Adipose
Recent advances in RNA sequencing (RNA-Seq) have enabled the discovery of novel transcriptomic variations that are not possible with traditional microarray-based methods. Tissue and cell specific transcriptome changes during pathophysiological stress, in disease cases versus controls and in response...
ORGANISM(S): Homo sapiens 
2013-07-12 | E-GEOD-46323 | biostudies-arrayexpress
TranscriptomicsTissue-specific RNA-seq in human evoked inflammation identifies novel blood and adipose lincRNA signatures of cardio-metabolic diseases
Inappropriate or sustained activation of innate immunity is a pathologic feature of several common cardio-metabolic disorders. Little is known, however, about transcriptomic modulation during inflammatory stress in disease-relevant human tissues. We applied deep RNA sequencing (RNA-seq) during low-d...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-50792 | biostudies-arrayexpress
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