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TranscriptomicsThe growth factor environment defines distinct pluripotent ground states in novel blastocyst derived stem cells
Pluripotent stem cell lines can be derived from blastocyst embryos, which yield embryonic stem cell lines (ES cells), as well as the post-implantation epiblast, which gives rise to epiblast stem cell lines (EpiSCs). Remarkably, ES cells and EpiSCs display profound differences in the combination of g...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-12519 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stem cell-derived fibroblasts, primary human fetal cells, and diverse cells of neonatal and adult human origin derived pluripotent stem cells (iPS) - reprogramming of human somatic cells to pluripotency with defined factors
Pluripotency, the capacity of embryo-derived stem cells to generate all tissues in the organism, can be induced in somatic cells by nuclear transfer into oocyte, fusion with embryonic stem cells, and for male germ cells by cell culture alone. Recently, murine fibroblasts have been reprogrammed direc...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-9832 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from mouse iPS cells, ES cells, and ntES cells
Genome-wide DNA methylation was studied to determine whether iPS cells retain epigenetic memory at loci associated with its tissue of origin. We used custom Nimblegen microarrays to determine the genome-wide DNA methylation in mouse iPS cells. We isolated genomic DNA from mouse stem cells and hybrid...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-22851 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (Dazl UV RNA-IP)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39541 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (Dazl knockdown)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39535 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (Dazl native RNA-IP)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39544 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (Dazl testis RNA-IP)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39545 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (in vitro, in vivo)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39546 | biostudies-arrayexpress
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