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UnknownComprehensive analysis of coding variants highlights genetic complexity in developmental and epileptic encephalopathy.
Although there are many known Mendelian genes linked to epileptic or developmental and epileptic encephalopathy (EE/DEE), its genetic architecture is not fully explained. Here, we address this incompleteness by analyzing exomes of 743 EE/DEE cases and 2366 controls. We observe that damaging ultra-ra...
S-EPMC6555845 | biostudies-literature
UnknownBaloxavir susceptibility of seasonal influenza viruses during the first seven seasons of clinical use in Japan, 2017/18 to 2023/24.

Background

Baloxavir marboxil, a cap-dependent endonuclease inhibitor, was approved in Japan in February 2018 for treatment of influenza A and B infections, making Japan the first country to introduce its clinical use.

Aim

We aimed to assess baloxavir susceptibility among seasonal inf...
S-EPMC12862291 | biostudies-literature
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