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MetabolomicsEndoplasmic reticulum-derived bodies enable a single-cell chemical defense in Brassicaceae plants
Brassicaceae plants have a dual-cell type of chemical defense against herbivory. Here we show a novel single-cell defense involving endoplasmic reticulum (ER)-derived organelles (ER bodies) and the vacuoles. We identify various glucosinolates as endogenous substrates of the ER-body β-glucosidases BG...
2020-02-04 | MTBLS1383 | MetaboLights
TranscriptomicsChIP-on-chip on BMP2 treated C2C12 cells transfected with FLAG tagged Alx3 expression vector
FLAG-binding DNA analysis using Agilent Mouse promoter 1M microarray Input vs FLAG-IP
ORGANISM(S): Mus musculus 
2013-03-05 | E-GEOD-44822 | biostudies-arrayexpress
TranscriptomicsLife-long caloric restriction-associated remodeling of rat white adipose tissue
This study explored the role of the growth hormone (GH) / insulin-like growth factor 1 (IGF-1) axis on the life-long caloric restriction (CR)-associated remodeling of white adipose tissue (WAT). Adipocyte size and gene expression profiles, using high-density oligonucleotide microarrays, were analyze...
ORGANISM(S): Rattus norvegicus 
2012-09-27 | E-GEOD-30668 | biostudies-arrayexpress
MetabolomicsMetabolite profiling of the fermentation process of yamahai-ginjo-shikomi Japanese sake
Sake is a traditional Japanese alcoholic beverage prepared by multiple parallel fermentation of rice. The fermentation process of yamahai-ginjo-shikomi sake is mainly performed by three microbes, Aspergillus oryzae, Saccharomyces cerevisiae, and Lactobacilli; the levels of various metabolites fluctu...
2018-06-29 | MTBLS451 | MetaboLights
TranscriptomicsMouse C2C12 cells treated with/without hBMP2
Bone morphogenetic proteins (BMPs) regulate many aspects of skeletal development, including osteoblast and chondrocyte differentiation, cartilage and bone formation, and cranial and limb development. Among them, BMP2, one of the most potent osteogenic signaling molecules, stimulates osteoblast diffe...
ORGANISM(S): Mus musculus 
2011-11-11 | E-GEOD-33567 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression profiles in human chronic kidney disease
A microarray analysis with renal biopsy specimens from CKD patients was conducted in order to identify the responsible genes associated with tubulointerstitial fibrosis and tubular cell injury in CKD. This study showed microarray profiles in total 53 biopsy specimens of CKD patients. In the discover...
ORGANISM(S): Homo sapiens 
2015-08-16 | E-GEOD-66494 | biostudies-arrayexpress
ProteomicsProximity biotinylation of A431 cells by EGFR-FabID
A431 cells were pretreated with DMSO or gefitinib and unstimulated or stimulated with EGF. Then AGIA-FabID or EGFR-FabID were added to the cells in three biological replicates. Cell lysates were subjected to methanol-chloroform precipitation and digested with trypsin. Biotinylated peptides were puri...
ORGANISM(S): Homo Sapiens (human) 
2023-11-14 | PXD039450 | JPOST Repository
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
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