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UnknownThe increase in cell volume and nuclear number of the koji-fungus <i>Aspergillus oryzae</i> contributes to its high enzyme productivity.
While the ratio of nuclei to cell volume is well regulated, it remains largely unexplored in multinucleate organisms. The koji-fungus Aspergillus oryzae, traditionally used in Japanese brewing and fermentation for over a thousand years, is now widely utilized in modern biotechnology as a host...
S-EPMC12456952 | biostudies-literature
UnknownGenome sequence of the white koji mold Aspergillus kawachii IFO 4308, used for brewing the Japanese distilled spirit shochu.
The filamentous fungus Aspergillus kawachii has traditionally been used for brewing the Japanese distilled spirit shochu. A. kawachii characteristically hyperproduces citric acid and a variety of polysaccharide glycoside hydrolases. Here the genome sequence of A. kawachii IFO 4308 was determined and...
S-EPMC3209066 | biostudies-literature
UnknownSingle-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity.
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 coronavirus disease 2019 (COVID-19) patie...
S-EPMC10181941 | biostudies-literature
UnknownThe whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.
Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individual...
S-EPMC9395416 | biostudies-literature
UnknownDeciphering state-dependent immune features from multi-layer omics data at single-cell resolution.
Current molecular quantitative trait locus catalogs are mostly at bulk resolution and centered on Europeans. Here, we constructed an immune cell atlas with single-cell transcriptomics of >1.5 million peripheral blood mononuclear cells, host genetics, plasma proteomics and gut metagenomics from 235 J...
S-EPMC12339405 | biostudies-literature
UnknownBlood DNA virome associates with autoimmune diseases and COVID-19.
Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, in...
S-EPMC11735405 | biostudies-literature
UnknownQuantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues.
Several X-linked genes escape from X chromosome inactivation (XCI), while differences in escape across cell types and tissues are still poorly characterized. Here, we developed scLinaX for directly quantifying relative gene expression from the inactivated X chromosome with droplet-based single-cell ...
S-EPMC11406184 | biostudies-literature
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