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UnknownGeneration of human hepatobiliary organoids with a functional bile duct from chemically induced liver progenitor cells.

Background

Liver disease imposes a significant medical burden that persists due to a shortage of liver donors and an incomplete understanding of liver disease progression. Hepatobiliary organoids (HBOs) could provide an in vitro mini-organ model to increase the understanding of the liver and...
S-EPMC11346037 | biostudies-literature
UnknownCharacteristics of chemically induced liver progenitors derived from a pig model of metabolic dysfunction-associated steatotic liver disease.
We previously reported the efficacy of chemically induced liver progenitors (CLiP) as a source of cells for transplantation in patients with liver disease. This study aimed to characterize CLiP derived from steatotic livers using a pig model for future clinical applications. Livers were removed from...
S-EPMC11620392 | biostudies-literature
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