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UnknownExtracellular RNA clearance by non-canonical cell-surface MDA5 protects against lung fibrosis.
The role of innate immune receptors, specifically RNA sensors, in non-pathogen-driven lung fibrosis remains unclear. Here, we demonstrate that the cytosolic RNA sensor MDA5 could translocate to the cell surface upon bleomycin-induced damage. MDA5-deficient mice exhibited exacerbated lung fibrosis wi...
S-SCDT-10_1038-S44321-026-00513-6 | biostudies-other
UnknownGut microbial composition in patients with atrial fibrillation: effects of diet and drugs.
Atrial fibrillation (AF) reduces the quality of life by triggering stroke and heart failure. The association between AF onset and gut metabolites suggests a causal relationship between AF and gut microbiota dysbiosis; however, the relationship remains poorly understood. We prospectively enrolled 34 ...
S-EPMC7788021 | biostudies-literature
UnknownImpact of body mass index on in-hospital mortality for six acute cardiovascular diseases in Japan.
Body mass index (BMI) distribution and its impact on cardiovascular disease (CVD) vary between Asian and western populations. The study aimed to reveal time-related trends in the prevalence of obesity and underweight and safe ranges of BMI in Japanese patients with CVD. We analyzed 5,020,464 records...
S-EPMC9640599 | biostudies-literature
UnknownA possible beneficial effect of Bacteroides on faecal lipopolysaccharide activity and cardiovascular diseases.
Faecal lipopolysaccharides (LPS) have attracted attention as potent elements to explain a correlation between the gut microbiota and cardiovascular disease (CVD) progression. However, the underlying mechanism of how specific gut bacteria contribute to faecal LPS levels remains unclear. We retrospect...
S-EPMC7398928 | biostudies-literature
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