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MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
ProteomicsA ubiquitin-based effector-to-inhibitor switch coordinates brain, craniofacial, and skin development
The molecular mechanisms that coordinate patterning of the embryonic ectoderm into spatially distinct lineages to form the nervous system, epidermis, and craniofacial structures are unclear. Here, biochemical disease-variant profiling reveals a posttranslational pathway that drives early ectodermal ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-14 | MSV000090711 | MassIVE
TranscriptomicsStudy of SPEN overexpression in T47D cells. (2)
We investigated the functions/pathways affected by SPEN in breast cancer by global expression profiling in a cell model, where the human breast cancer cell line, T47D, were transfected with an expression vector coding for SPEN.
ORGANISM(S): Homo sapiens 
2015-10-21 | E-MTAB-2182 | biostudies-arrayexpress
TranscriptomicsStudy of SPEN knockdown in MCF-7 cells. (2)
We investigated the functions/pathways affected by SPEN knockdown in breast cancer by global expression profiling in a cell model, where the human breast cancer cell line, MCF-7, were transfected with an shRNA targeting SPEN mRNA.
ORGANISM(S): Homo sapiens 
2015-10-21 | E-MTAB-2183 | biostudies-arrayexpress
UnknownClinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs.
Not available
S-EPMC12075701 | biostudies-literature
TranscriptomicsAedes aegypti whole-genome gene expression
Sequencing of the Aedes aegypti genome has enabled genome-wide studies of gene expression in this mosquito. The large quantities of data produced from such studies require efficient cataloguing in order for new insight to be made into gene expression patterns and the underlying molecular mechanisms...
ORGANISM(S): Aedes aegypti 
2010-07-05 | E-GEOD-22339 | biostudies-arrayexpress
UnknownROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo.
Not available
S-EPMC7299545 | biostudies-literature
ProteomicsG9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered TCR-T cells against hepatocellular carcinoma
Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of engineered T cell therapy as they carry no risk of insertional mutagenesis or long-term adverse side-effects. However, multiple rounds of treatment are often required, increasing patient discomfort and cost...
ORGANISM(S): Homo Sapiens (human) 
2023-01-19 | PXD039542 | JPOST Repository
TranscriptomicsDeletion of Scap in Alveolar Type II Cells Influences Lung Lipid Homeostasis and Identifies a Compensatory Role for Pulmonary Lipofibroblasts
Pulmonary function after birth is dependent upon surfactant lipids that reduce surface tension in the alveoli. The sterol-responsive element-binding proteins (SREBPs) are transcription factors regulating expression of genes controlling lipid homeostasis in many tissues. To identify the role of SREBP...
ORGANISM(S): Mus musculus 
2011-01-08 | E-GEOD-26496 | biostudies-arrayexpress
UnknownKIR-HLA interactions extend human CD8+ T cell lifespan in vivo.
Not available
S-EPMC10266773 | biostudies-literature
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