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TranscriptomicsRIP-seq of livers in C57BL/6J mice with antibodies against Cnot3, Ago2, and BRF1
Shortening of polyadenosine (poly(A)) tails (deadenylation) is the initial step in the decay of most mRNAs. The CCR4-NOT complex is the major deadenylase in mammals. Interaction of Cnot1 with RNA binding proteins, including the miRNA-induced silencing complex (miRISC), which includes Argonaute (Ago)...
ORGANISM(S): Mus musculus 
2020-03-30 | E-MTAB-6941 | biostudies-arrayexpress
TranscriptomicsRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Gene expression is balanced by transcription and mRNA degradation. Shortening of polyadenosine (poly(A)) tails (deadenylation) is the initial step in the decay of most mRNAs. However, the mechanism by which deadenylation controls mRNA expression is not fully understood. This experiment aimed to dete...
ORGANISM(S): Mus musculus 
2020-03-30 | E-MTAB-5901 | biostudies-arrayexpress
TranscriptomicsA specialized mechanism of translation mediated by FXR1a-associated microRNP in cellular quiescence
MicroRNAs predominantly decrease gene expression; however, specific mRNAs are translationally upregulated in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes by an FXR1a-associated microRNP (microRNA-protein complex) that lacks the microRNP repressor, GW182. We conducted global pro...
ORGANISM(S): Homo sapiens 
2016-02-03 | E-GEOD-77512 | biostudies-arrayexpress
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