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TranscriptomicsSkin gamma delta T cells in Obesity
Epithelial cells provide an initial line of defense against damage and pathogens in barrier tissues such as the skin; however this balance is disrupted in obesity and metabolic disease. Skin gamma delta T cells recognize epithelial damage and release cytokines and growth factors that facilitate wou...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-22196 | biostudies-arrayexpress
UnknownTP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.
Not available
S-EPMC5815403 | biostudies-literature
MetabolomicsAssessing the impact of nitrogen supplementation in oats across multiple growth locations and years with targeted phenotyping and high-resolution metabolite profiling approaches
Oats (Avena sativa L.) are a healthy food, being high in dietary fibre (e.g. β-glucans), antioxidants, minerals, and vitamins. Understanding the effect of variety and crop management on nutritional quality is important. The response of four oat varieties to increased nitrogen levels was investigated...
2021-04-26 | MTBLS1801 | MetaboLights
ProteomicsMonitor precursor mass shifts of Halobacterium salinarum
Approximately 2x106 CL1-5 and H23 cells were seeded on 10-cm dishes with RPMI-1640 medium containing 10% fetal bovine serum. After the cells covered 80% of the dish, cells were serum-starved for 24 h in RPMI-1640 medium. CL1-5 and H23 cell lysates were harvested, trypsinized and analyzed by using LT...
ORGANISM(S): Homo sapiens (Human) Halobacterium salinarum 
2020-01-14 | PXD000082 | Pride
Cl1-5 lysate Nrc-1 gvd lysate Nrc-1 lysate Ltq-orbitrap xl Ltq-orbitrap discovery H23 lysate Human nsclc cell line Halobacterium salinarum nrc-1 Lc-ms/ms 
TranscriptomicsMicroarray profiling reveals broad and differential effects of RBM3 on miRNA expression.
MicroRNAs (miRNAs) are a family of short, noncoding RNAs that regulate translation of mRNAs by mechanisms involving the binding of complementary sequences. The influence of miRNAs on the proteome and cellular events is extensive as they regulate an estimated 60% of the transcriptome and play key ro...
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-33519 | biostudies-arrayexpress
TranscriptomicslincRNAs act in the circuitry controlling pluripotency and differentiation
While thousands of large intergenic non-coding RNAs (lincRNAs) have been identified in mammals, few have been functionally characterized leading to debate about their biological role. To address this, we performed loss-of-function studies on most lincRNAs expressed in mouse embryonic stem cells (ESC...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-30245 | biostudies-arrayexpress
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
GenomicsGenome-wide map of HBO1 in cancer derived human cell line
We used ChIP-seq technology in order to map chromatin binding sites of the HBO1 MYST complex in the RKO cell line. We obtained a significant enrichment of the HBO1 signal right after TSS regions of genes and also In the proximal promoter region, with no signal on TSS. This enrichment also correlates...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-33007 | biostudies-arrayexpress
TranscriptomicsEffects of the JADE-HBO1 complex on gene expression
We find that 499 genes are up-regulated and 457 are down-regulated in response to over-expression of JADE1, while 397 genes are up-regulated and 385 are down-regulated after HBO1 knock-down. For each condition - HBO1 siRNA treatment or JADE1 over-expression - two biological replicates were analyzed ...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-33220 | biostudies-arrayexpress
TranscriptomicsImpact of ectopic expression of SNAIL2, ZEB2, ZEB1 or TWIST1 on BRAF-target genes in the murine melanocytic melan-a cell line
We have demonstrated that the oncogenic activation of B-RAF (using a truncated delta-BRAF-ER version inducible with tamoxifen) in the melan-a melanocyte cell line triggers the activation of Zeb1 and Twist1 at the expanse of Zeb2 and Snail2. Enforced maintenance of Zeb2 or Snail2 expression reduces t...
ORGANISM(S): Mus musculus 
2013-10-29 | E-GEOD-39030 | biostudies-arrayexpress
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