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MetabolomicsTranscriptome and metabolome changes in Chinese cedar during cold acclimation reveal the roles of flavonoids in needle discoloration and cold resistance

Cryptomeria fortunei growth and development are usually affected by low temperatures. Despite the evergreen nature of this species, most needles turn yellowish-brown in cold winters. The underlying discoloration mechanisms that cause this phenomenon in response to cold acclimation remain...

2022-08-12 | MTBLS3184 | MetaboLights
TranscriptomicsEnhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity1-4. Crucial for T helper17 (Th17) cells in vivo5,6, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argu...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23505 | biostudies-arrayexpress
TranscriptomicsRoles of STAT3 and STAT5 in regulation of gene expression under Th17 differentiation
Interleukin 2 (IL-2), a cytokine linked to human autoimmune diseases, limits IL-17 production. We show that deletion of Stat3 in T cells abrogates IL-17 production and attenuates autoimmunity associated with IL-2 deficiency. While STAT3 induces IL-17 and ROR?t and inhibits Foxp3, IL-2 inhibited IL-1...
ORGANISM(S): Mus musculus 
2011-02-09 | E-GEOD-26551 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of murine WT and DNR Tregs
Donminant negative transform growth factor receptor II (DNR) mice were served as a murine primary biliary cirrhrosis model. CD4+Foxp3+ Regulatory T cells (Tregs) play a critical role in self-tolerance and in regulating PBC. In order to determine whether DNR mice derived Tregs processed defective fu...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-62964 | biostudies-arrayexpress
TranscriptomicsMDA-MB-231 cell: infected with lentivirus to stably express mut-Elf5 vs WT-Elf5
Elf5 induced transcriptional changes in MDA-MB-231 origin, control (mut Elf5) vs WT ELF5 Two-condition experiment, control (mut-Elf5) vs WT-Elf5. Each has 3 biological repeats.
ORGANISM(S): Homo sapiens 
2012-09-20 | E-GEOD-32144 | biostudies-arrayexpress
TranscriptomicsInterleukin-27 priming of T cells controls Interleukin-17-production in trans via induction of Programmed cell death ligand 1
Interleukin (IL)-27 is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27 might exert its immunosuppressive effect, we analyzed genes in T cells rapidly induced by IL-27. We found that IL-27 priming of naïve T cells upregu...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-38375 | biostudies-arrayexpress
UnknownLongitudinal MRI Characterization of T<sub>1</sub> and T<sub>2</sub> Relaxation Times in an Amyloid Mouse Model of Alzheimer's Disease at 11.7 T.
Not available
S-EPMC12634190 | biostudies-literature
GenomicsGlobal methylation alterations in Dnmt3aKO derived malignancies
To test the long-term effects of lack of Dnmt3a on mouse HSCs, we established a cohort of lethally irradiated mice transplanted with Dnmt3a-KO or WT HSC control cells. Dnmt3a deletion in purified HSCs transplanted alone leads to an array of hematologic disorders that models the spectrum of disorders...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-60264 | biostudies-arrayexpress
ProteomicsInhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon responses via MYC/CDK2/DNMT1 pathway
label-free quantitative proteomics for WT and sgNAT10 TC1 cells. The LC-MS data were analyzed for data interpretation and protein identification against the Mus musculus database from Uniprot (downloaded on 01/02/2021, and including 88069 protein sequences), which is sourced from the protein databas...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-16 | PXD059463 | Pride
N-acetyltransferase 10  type i ifn  cd8+ t cell  immunotherapy 
UnknownDiscovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2.
Not available
S-EPMC11129194 | biostudies-literature
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