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UnknownInherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.
Not available
S-EPMC4375304 | biostudies-literature
TranscriptomicsGenome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila
Polycomb group (PcG) proteins maintain transcriptional repression of developmentally important genes and have been implicated in cell proliferation and stem-cell self-renewal. We used a genome-wide approach to map binding patterns of PcG proteins (Pc, esc and Sce) in Drosophila Kc cells. We found th...
ORGANISM(S): Drosophila melanogaster 
2010-06-11 | E-GEOD-4564 | biostudies-arrayexpress
UnknownProcyanidin B2 improves endothelial progenitor cell function and promotes wound healing in diabetic mice via activating Nrf2.
Not available
S-EPMC7812287 | biostudies-literature
TranscriptomicsNotch/HES1-mediated PARP1 activation: A cell-type specific mechanism for tumor suppression
Notch signaling plays both oncogenic and tumor suppressor roles, depending on cell type. In contrast to T cell acute lymphoblastic leukemia (T-ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B-ALL leads to growth arrest and apoptosis. The Notch target Hairy/Enha...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-26366 | biostudies-arrayexpress
UnknownCombinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context.
Not available
S-EPMC12485930 | biostudies-literature
TranscriptomicsEZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B-cells and targeted by somatic mutations in B-cell lymphomas. Here we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions in mice. EZH2 represses proliferation checkpoint genes and h...
ORGANISM(S): Homo sapiens 
2013-05-13 | E-GEOD-45982 | biostudies-arrayexpress
TranscriptomicsEnhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity1-4. Crucial for T helper17 (Th17) cells in vivo5,6, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argu...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23505 | biostudies-arrayexpress
GenomicsPCGP Ph-likeALL RNASeq - samples
DATA FILES FOR SJPhLike-RNASeq
EGAD00001001016 | EGA
GenomicsPCGP Ph-likeALL SNP6 - samples
PCGP Ph-likeALL SNP6
EGAD00010000598 | EGA
GenomicsPCGP Ph-likeALL WES - samples
DATA FILES FOR Ph-likeALL WES
EGAD00001001054 | EGA
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