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MetabolomicsUntargeted Metabolomics of the enthesis interstitial fluid of wild-type and Nlrp3-/- mice with sham operation and injury post 7 days
In order to investigate the effect of the NLRP3 inflammasome on the regeneration of enthesis, we established an enthesis injury and repair model in wild-type and NLRP3-/- mice. The interstitial fluid of enthesis was extracted, and untargeted metabolomics was conducted to discover differential metabo...
2025-07-08 | MTBLS12150 | MetaboLights
TranscriptomicsReversal of Aberrant Cancer Methylome and Transcriptome upon Direct Reprogramming of Lung Cancer Cells.
This SuperSeries is composed of the following subset Series: GSE35911: Reversal of Aberrant Cancer Methylome and Transcriptome upon Direct Reprogramming of Lung Cancer Cells [Expression] GSE35912: Reversal of Aberrant Cancer Methylome and Transcriptome upon Direct Reprogramming of Lung Cancer Cells ...
ORGANISM(S): Homo sapiens 
2012-08-27 | E-GEOD-35913 | biostudies-arrayexpress
ProteomicsGPX4 immunoprecipitation in Huh7 cells
Huh7 cells with expression of Flag-GPX4 were treated with IGF1. An immunoprecipitation assay was performed, and immunoprecipitates were subjected to masspec analysis.
ORGANISM(S): Human 
2023-02-22 | MSV000091343 | MassIVE
MetabolomicsUntargeted metabolites of supernatant of wild-type and Nlrp3-/- bone marrow-derived macrophages with or without LPS and ATP costimulation
Untargeted metabolites of supernatant of wild-type and Nlrp3-/- bone marrow-derived macrophages without stimulation or with 4 hours of LPS preconditioning and subsequently 30 min of ATP stimulation.
2025-07-08 | MTBLS12152 | MetaboLights
ProteomicsProteome of uterine cavity fluid in female rattus
The injection with GnIH/saline through the lateral ventricle. At 6 h after injection, the protein components of rats in the experimental and control groups were analyzed using Liquid Chromatography (LC)-Mass Spectrometry (MS)/MS.
ORGANISM(S): Rattus Rattus 
2022-10-31 | PXD037826 |
ProteomicsTRIM55 promotes noncanonical NF-kB signaling and B-cell-mediated immune responses by coordinating p100 ubiquitination and processing
The ubiquitination-dependent processing of NF-B2 (also known as p100) is a critical step in the activation of the noncanonical NF-B pathway. We investigated the molecular mechanisms regulating this process and showed that TRIM55 was the ubiquitin E3 ligase that mediated the ubiquitination of p100 ...
ORGANISM(S): Mus Musculus 
2023-08-28 | PXD044895 |
ProteomicsLabel-free proteomic analysis of apoptotic, necrotic and necroptotic DAMPs from HNSCC cells
Necroptosis is a newly discovered form of programmed cell death (PCD) showing necrotic features, including membrane permeabilization and the release of damage-associated molecular patterns (DAMPs). Studies have revealed both its tumorigenic role and therapeutic potential in various cancers, yet its ...
ORGANISM(S): Homo Sapiens 
2022-07-16 | PXD035379 |
ProteomicsThe plasma DIA proteomic analysis for humans aimming at exploring the mechanism of RIPC’s protective effect under hypobaric hypoxia condition.
The plasma proteome profiling data come from the humans who received remote ischemic preconditioning treatment and experienced hypobaric hypoxia exposure then.
ORGANISM(S): Homo Sapiens 
2022-01-25 | PXD031247 |
ProteomicsA chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer
Through chemical probe screening, we uncovered a novel mechanism of RNA splicing in paclitaxel-resistant TNBC and identified PRMTs as therapeutic targets.
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053336 |
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