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TranscriptomicsTranscription profiling of human stage non-small cell lung cancer samples, metaanalysis for a predictive signature
We applied a meta-analysis of datasets from seven different microarray studies on lung cancer for differentially expressed genes related to survival time (under 2 y and over 5 y). Systematic bias adjustment in the datasets was performed by distance-weighted discrimination (DWD). We identified a gene...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6253 | biostudies-arrayexpress
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
TranscriptomicsA Role for Small RNAs in DNA Double-Strand Break Repair
Here we identify a novel class of small RNAs that are ~21-nucleotide in length and are produced from the sequences in the vicinity of DNA double strand break (DSB) sites in Arabidopsis and humans. We named them diRNAs for DSB-induced small RNAs. In Arabidopsis, the biogenesis of diRNAs requires the ...
ORGANISM(S): Arabidopsis thaliana 
2012-03-26 | E-GEOD-36338 | biostudies-arrayexpress
TranscriptomicsMicroRNAs in a multicellular green alga Volvox carteri
We identified 174 miRNAs expressed in Volvox carteri. Some of Volvox miRNAs are highly enriched in gonidia or somatic cells. Subsequently, we predicted the targets of Volvox miRNAs and found many of target genes were regulated through mRNA degradation. Conservation analysis suggests the common origi...
ORGANISM(S): Volvox carteri 
2014-02-08 | E-GEOD-52345 | biostudies-arrayexpress
TranscriptomicsCytoplasmic Assembly and Selective Nuclear Import of Arabidopsis ARGONAUTE4/siRNA Complexes
Here we profiled small RNAs from whole cell, cytoplasmic and nuclear extracts from three-week-old Arabidopsis seedlings. We unexpectedly found that nuclear functional hc-siRNAs are predominantly present in the cytoplasm. Samples from Arabidopsis thaliana whole cell, cytoplasmic and nuclear extract...
ORGANISM(S): Arabidopsis thaliana 
2012-07-12 | E-GEOD-36500 | biostudies-arrayexpress
GenomicsAn East-Asian polymorphism underlies BCR-ABL mutation-independent resistance to tyrosine kinase inhibitors in chronic myelogenous leukemia
We used massively parallel DNA sequencing of paired-end ditags (DNA-PET) to identify structural genetic factors associated with disease progression and drug-resistance in representative samples from four CML patients and one CML cell line. The functional consequences of our genetic findings were ev...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-28303 | biostudies-arrayexpress
ProteomicsUrine proteomics in primary antiphospholipid syndrome
In this study, using proteomics study of urine samples from patients with primary APS (PAPS) and healthy controls (HC), we identified several proteins that discriminated Obstetric APS (OAPS) and Thrombotic APS (TAPS) from each other, as well as from HC.
ORGANISM(S): Homo Sapiens 
2021-08-04 | PXD027694 |
UnknownComparison of the Oral Calcimimetics Evocalcet and Cinacalcet in East Asian Patients on Hemodialysis with Secondary Hyperparathyroidism.
Not available
S-EPMC10658267 | biostudies-literature
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