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MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
TranscriptomicsExpression data from gastric cancer and paried normal tissues
Gastric cancer (GC) is one of the most common cancer worldwide. Specific and reliable molecular markers are limited; it is critical to identify new biomarkers for GC to aid in early diagnosis, treatment strategy, and prognosis evaluation. Microarray technology makes it possible to measure the expres...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-GEOD-79973 | biostudies-arrayexpress
TranscriptomicsFundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer [Methylation profiling by array]
Genetic and epigenetic alterations are essential for the initiation and progression of human cancer. We previously reported that primary human medulloblastomas showed extensive cancer-specific CpG island DNA hypermethylation in critical developmental pathways. To determine whether genetically engine...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-45240 | biostudies-arrayexpress
UnknownInitial clinical characteristics of gravid severe acute respiratory syndrome coronavirus 2-positive patients and the risk of progression to severe coronavirus disease 2019.
Not available
S-EPMC8017918 | biostudies-literature
TranscriptomicsTranscription profiling of mouse erythroid differentiation using Gata1 gene-disrupted G1E ER4 clone cells
Analysis of erythroid differentiation using Gata1 gene-disrupted G1E ER4 clone cells. Estradiol addition activates an ectopically expressed Gata-1-estrogen receptor fusion protein, triggering synchronous differentiation. 30 hour time course corresponds roughly to late burst-forming unit-erythroid st...
ORGANISM(S): Mus musculus 
2009-09-18 | E-GEOD-18042 | biostudies-arrayexpress
TranscriptomicsAdult human liver tissue expression (Affymetrix)
The human liver plays a vital role in meeting the body's metabolic needs and maintaining homeostasis. To address the molecular mechanisms of liver function, we integrated multiple gene expression datasets from microarray, MPSS, SAGE and EST platforms to generate a transcriptome atlas of the normal h...
ORGANISM(S): Homo sapiens 
2010-09-18 | E-GEOD-24042 | biostudies-arrayexpress
UnknownTreatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3.
Not available
S-EPMC5652397 | biostudies-literature
ProteomicsIdentification of pharmacokinetic markers for safflower injection using a combination of system pharmacology, multicomponent pharmacokinetics, and quantitative proteomics study
Safflower injection (SI), a water-extract preparation from safflower (Carthamus tinctorius L.), has been widely used for the treatment of cardio-cerebrovascular diseases. This work aims to develop an approach for identifying PK markers of cardiovascular herbal medicines using SI as a case study. Fir...
ORGANISM(S): Rattus Norvegicus 
2022-11-15 | PXD038145 |
TranscriptomicsIdentifying mRNA targets of microRNA in clear cell renal cell carcinoma
A bioinformatic approach to identify targets of microRNA in cancer. Keywords: Patient sample study Samples GSM413237-GSM413270: Total RNA from 17 RCC tumors and 17 corresponding non-tumor samples was hybridized against a common reference RNA (Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-16441 | biostudies-arrayexpress
MetabolomicsMulti-omics-identified StAPR3 enhances potato Cd tolerance and tuber quality via sulfur metabolism and glutathione redox homeostasis

Cadmium (Cd) in agricultural soils inhibits potato growth, disrupts tuber development, and causes Cd accumulation in edible tubers, threatening food safety. Here, we determined the EC50 of Cd in potato, which induced oxidative stress and chloroplast damage. Transcriptomic and metabolomic co-analy...

2026-09-04 | MTBLS15532 | MetaboLights
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