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TranscriptomicsPi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [microarray]
Background—YAP, the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEAD sequence specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the d...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-57718 | biostudies-arrayexpress
TranscriptomicsYap and Taz in Neural Crest play a Crucial Role in Smooth Muscle Development
We conditionally knocked out both Yap and Taz in cranial neural crest (CNC) using the Wnt1Cre driver and sequenced mRNA from embryonic day 10.5 mandibles. Examination of mRNA level in E10.5 mandibular tissues from control and Wnt1Cre Taz and Yap dKO mutant.
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-69311 | biostudies-arrayexpress
TranscriptomicsDiscovery of immediate YAP target genes with inducible form of YAP
Microarray analyses with cells/tissues overexpressing YAP have revealed many transcription targets of YAP (Dong et al, 2007; Zhao et al, 2008). However, as YAP induces transformation of non-cancerous cells, we thought many of known targets of YAP may be indirect consequence of transforming property ...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-60579 | biostudies-arrayexpress
ProteomicsEndothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Activation of endothelial YAP/TAZ signaling is crucial for physiological and pathological angiogenesis. The mechanisms of endothelial YAP/TAZ regulation are, however, incompletely understood. Here we report that the protocadherin FAT1 acts as a critical upstream regulator of endothelial YAP/TAZ whic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-14 | MSV000091279 | MassIVE
TranscriptomicsRSpondin1 treatment of control and Yap cKO mice
RSpondin1 adenovirus was administered to mice and intestine was isolated for expression analysis 1 week later. Yap control and cKO mice were given Rspondin virus and sacrificed 1 week later.
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-41507 | biostudies-arrayexpress
TranscriptomicsExpression data from YAP-S127D DLD1 Xenografts
We overexpressed YAP-S127D in DLD1 colorectal cancer cells for 21 days after sub-cutaneous (SubQ) injection into the flanks of nude mice. Mice were given dox for 21 days, sacrificed, and tumors were isolated for RNA extraction and analyzed by Affymetrix microarrays.
ORGANISM(S): Homo sapiens 
2012-11-29 | E-GEOD-41508 | biostudies-arrayexpress
TranscriptomicsEffect of YAP overexpression on HuCCT1 cholangiocarcinoma cell line transcriptome (YAPS94A)
The YAP pathway in regulating organ size by integrating external signals to control the expression of genes involved in cell proliferation. YAP is known to be involved in tumorigenesis in several tissues, yet its role in cholangiocarcinoma is not established We used microarrays to assess the role of...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-69655 | biostudies-arrayexpress
TranscriptomicsExpression data from YAP-S127A Villin-rtTA crypts
We overexpressed YAP in the intestinal epithelium by adding doxycycline to the drinking water of experimental mice. Mice were given dox for 2 days, and referred to as Tg (transgenic). Mice were given dox for 2 days, sacrificed, and crypts were isolated for RNA extraction and analyzed by Affymetrix m...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-41506 | biostudies-arrayexpress
TranscriptomicsExpression analysis of YAP and Angiomotin target genes
To assess changes in gene expression regulated by Yap1 or Angiomotin, either Yap1 or Angiomotin were knocked down in HEK293 cells using shRNA and expression was assessed by microarray analysis and compared to expression patterns of wildtype cells. Microarray analysis was performed to compare gene...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-49406 | biostudies-arrayexpress
TranscriptomicsA systems approach to delineate functions of YAP family members
Duplication of genes encoding transcription factors plays an essential role in driving phenotypic variation. Because regulation can occur at multiple levels, it is often difficult to discern how each duplicated factor achieves its regulatory specificity. In these cases, a systems approach may distin...
ORGANISM(S): Saccharomyces cerevisiae 
2008-02-03 | E-GEOD-10146 | biostudies-arrayexpress
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