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ProteomicsA YAP/TAZ-TEAD signaling module links endothelial nutrient acquisition to angiogenic growth
Angiogenesis, the process by which endothelial cells (ECs) form new blood vessels from existing ones, is intimately linked to the tissue's metabolic milieu and often occurs at nutrient-deficient sites. However, ECs rely on sufficient metabolic resources to support growth and proliferation. How endot...
ORGANISM(S): Homo sapiens (Human) 
2022-05-08 | PXD026872 | Pride
Yap/taz-tead signaling Mtorc1 Endothelial cells Angiogenesis Nutrient acquisition 
TranscriptomicsThe transcriptional regulators TAZ and YAP direct Transforming Growth Factor-beta-induced tumorigenic phenotypes in breast cancer cells
Uncontrolled Transforming growth factor-beta (TGFβ) signaling promotes aggressive metastatic properties in late-stage breast cancers. However, how TGFβ-mediated cues are directed to induce late-stage tumorigenic events is poorly understood, particularly given that TGFβ has clear tumor suppressing ac...
ORGANISM(S): Homo sapiens 
2014-04-02 | E-GEOD-56445 | biostudies-arrayexpress
UnknownNuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer.
Not available
S-EPMC11066040 | biostudies-literature
GenomicsAn allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
PRJNA952667 | ENA
UnknownIn vitro evaluation of Verteporfin and exploration of TEAD palmitoylation inhibition in Piezo1-YAP/TAZ signaling and ECM remodeling.
Not available
S-EPMC12715214 | biostudies-literature
UnknownTargeting YAP/TAZ-TEAD signaling as a therapeutic approach in head and neck squamous cell carcinoma.
Not available
S-EPMC12044704 | biostudies-literature
UnknownIdentification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ-TEAD Biosensors.
Not available
S-EPMC6826516 | biostudies-literature
UnknownAn allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance.
Not available
S-EPMC10293011 | biostudies-literature
UnknownTargeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches.
Not available
S-EPMC5453487 | biostudies-literature
UnknownA YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.
Not available
S-EPMC9236904 | biostudies-literature
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