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TranscriptomicsDiscovery of immediate YAP target genes with inducible form of YAP
Microarray analyses with cells/tissues overexpressing YAP have revealed many transcription targets of YAP (Dong et al, 2007; Zhao et al, 2008). However, as YAP induces transformation of non-cancerous cells, we thought many of known targets of YAP may be indirect consequence of transforming property ...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-60579 | biostudies-arrayexpress
TranscriptomicsExpression data from YAP-S127A Villin-rtTA crypts
We overexpressed YAP in the intestinal epithelium by adding doxycycline to the drinking water of experimental mice. Mice were given dox for 2 days, and referred to as Tg (transgenic). Mice were given dox for 2 days, sacrificed, and crypts were isolated for RNA extraction and analyzed by Affymetrix m...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-41506 | biostudies-arrayexpress
TranscriptomicsEffect of YAP overexpression on HuCCT1 cholangiocarcinoma cell line transcriptome (YAPS94A)
The YAP pathway in regulating organ size by integrating external signals to control the expression of genes involved in cell proliferation. YAP is known to be involved in tumorigenesis in several tissues, yet its role in cholangiocarcinoma is not established We used microarrays to assess the role of...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-69655 | biostudies-arrayexpress
GenomicsPi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [ChIPseq]
Background—YAP, the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEAD sequence specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the d...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-57717 | biostudies-arrayexpress
TranscriptomicsYAP conveys an invasive phenotype to clear cell renal cell carcinoma cell lines via endothelin-2
To determine the biological mechanisms underlying the oncogenic properties of YAP in ccRCC the human ccRCC cell line MZ1774 was transduced with lentivirus containing a shRNA-cassette targeting YAP-mRNA. Expression profiles of MZ1774 YAP knockdown cells were compared to mock-transduced control cells....
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-50053 | biostudies-arrayexpress
TranscriptomicsExpression analysis of YAP and Angiomotin target genes
To assess changes in gene expression regulated by Yap1 or Angiomotin, either Yap1 or Angiomotin were knocked down in HEK293 cells using shRNA and expression was assessed by microarray analysis and compared to expression patterns of wildtype cells. Microarray analysis was performed to compare gene...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-49406 | biostudies-arrayexpress
GenomicsTead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition (ChIP-seq)
Cellular changes during an epithelial-mesenchymal transition (EMT) largely rely on global changes in gene expression orchestrated by transcription factors. Tead transcription factors and their co-factors Yap and Taz have been shown to be implicated in EMT, nevertheless, their direct target genes dur...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55709 | biostudies-arrayexpress
TranscriptomicsAnalysis of Liver Progenitor Cells Generated from Yap Expression [Set 2]
Hippo signaling is highly associated with activity in the stem cell compartment of many epithelial tissues. In this study, we examined if Hippo signaling inhibition (by inducing Yap expression) could convert differentiated cells into a progenitor like phenotype. Rosa26-lsl-YFP mice had recombinatio...
ORGANISM(S): Mus musculus 
2014-06-06 | E-GEOD-55559 | biostudies-arrayexpress
GenomicsPi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-57719 | biostudies-arrayexpress
TranscriptomicsEffect of YAP overexpression on HuCCT1 cholangiocarcinoma cell line transcriptome (YAP overexpression)
The YAP pathway in regulating organ size by integrating external signals to control the expression of genes involved in cell proliferation. YAP is known to be involved in tumorigenesis in several tissues, yet its role in cholangiocarcinoma is not established We used microarrays to assess the role of...
ORGANISM(S): Homo sapiens 
2015-10-27 | E-GEOD-61764 | biostudies-arrayexpress
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