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TranscriptomicsOpen lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage
Introduction: The ideal ventilation strategy for patients with massive brain damage requires better elucidation. We hypothesized that in the presence of massive brain injury, a ventilation strategy using low (6 mL/kg) tidal volume (VT) ventilation with open lung positive end-expiratory pressure set ...
ORGANISM(S): Rattus norvegicus 
2014-04-24 | E-GEOD-52142 | biostudies-arrayexpress
TranscriptomicsThe expression of inflammatory genes in endothelial cells is inhibited by N-octanoyl dopamine via modulation of the NFkB pathway
Background: Dopamine has intrinsic receptor-independent anti-inflammatory properties when used at high concentrations. Since cellular uptake of N-octanoyl dopamine (NOD) is far better than of dopamine, NOD might display anti-inflammatory effects already at relative low concentrations. The present st...
ORGANISM(S): Homo sapiens 
2012-08-30 | E-GEOD-34059 | biostudies-arrayexpress
TranscriptomicsModulation of brain dead induced inflammation by vagus nerve stimulation
Because the vagus nerve is implicated in control of inflammation, we investigated if brain death causes impairment of the parasympathetic nervous system, hence contributing to inflammation. Brain death (BD) was induced in rats. Anaesthetised ventilated rats (NBD) served as control. Heart rate varia...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-16483 | biostudies-arrayexpress
TranscriptomicsN-octanoyl dopamine treatment of endothelial cells induces the unfolded protein response and results in hypometabolism and tolerance to hypothermia
N-octanoyl dopamine (NOD), but not dopamine dose dependently induces the UPR. This was also found for other synthetic N-Acyl dopamine derivates (NADD). Induction of the UPR was dependent on the redox activity of NADD and was not caused by selective activation of a particular UPR sensor. UPR inductio...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-56285 | biostudies-arrayexpress
TranscriptomicsInhibition of VCAM-1 expression by CORM-3: the role of the ubiquitin proteasome system, p38 and mitochondrial respiration
Carbon monoxide (CO) abrogates TNF-alpha mediated inflammatory responses in endothelial cells, yet, the underlying mechanism hereof is still elusive. We sought to explore potential mechanisms by which CO down-regulates VCAM-1 expression on TNF-alpha stimulated human umbilical vein endothelial cells ...
ORGANISM(S): Homo sapiens 
2011-07-11 | E-GEOD-22175 | biostudies-arrayexpress
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