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ProteomicsSILAC identifies LAD1 as an oncogenic filamin binder regulating actin dynamics in response to EGF and marking aggressive breast tumors
Mutations mimicking growth factor-induced proliferation and motility characterize aggressive subtypes of mammary tumors. To unravel novel players, we applied phosphoproteomics on untransformed mammary cells, which were pre-stimulated with the epidermal growth factor (EGF). This analysis identified l...
ORGANISM(S): Homo sapiens (Human) 
2019-11-19 | PXD008100 | Pride
Lad1 egf phosphoproteome 
ProteomicsProteomics of HeLa cells starved and treated with YWF or leptomycin B
HeLa cells labeled with SILAC and were amino acids starved and treated with YWF, leptomycin B, MG132 or chloroquine. Cells were lysed with a 8M Urea buffer and proteins were reduced and alkylated. Equal amount of proteins of different labels were mixed and were digested with trypsin and resulting pe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-01 | MSV000092564 | MassIVE
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