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TranscriptomicsCultured chicken embryonic hepatocytes (CEH) exposed to linear PFOS (L-PFOS) or technical-grade PFOS (T-PFOS)
Recently it was discovered that the perfluorooctane sulfonate (PFOS) detected in wildlife, such as fish-eating birds, had a greater proportion of linear PFOS (L-PFOS) than the manufactured technical product (T-PFOS), which contains linear and branched isomers. This suggests toxicological studies bas...
ORGANISM(S): Gallus gallus 
2011-10-28 | E-GEOD-33291 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of adult male whole MutaMouse lung with its immortalized 100% confluent epithelial lung cell line counterpart (agilent array)
Biological comparison of gene expression profiles of adult male whole Muta?Mouse lung with its immortalized 100% confluent epithelial lung cell line counterpart. White, P.A.,et al. 2003. Development and characterization of an epithelial cell line from Muta?Mouse lung. Environ Mol Mutagen 42,3 pgs...
ORGANISM(S): Mus musculus 
2004-07-01 | E-MEXP-111 | biostudies-arrayexpress
TranscriptomicsReference: MicroRNA expression profiling in adult mouse liver following BaP treatment [Agilent miRNA array]
We have investigated the effect of exposure to 150 mg/kg benzo(a)pyrene (BaP) for 3 days on mRNA and miRNA expression levels in adult mouse liver. We used Agilent miRNA array platforms to assess effects of BaP exposure on miRNA expression levels. Our results indicate a distinct lack of effect of BaP...
ORGANISM(S): Mus musculus 
2010-10-28 | E-GEOD-19438 | biostudies-arrayexpress
TranscriptomicsmiRNA 135b regulation of inflammation
RT-PCR analysis of inflammatory cytokines and receptors in pEGP-miR-135b over-expressing cells compard to controls (pEGP-miR-null) using pathway-specific PCR arrays for the evaluation of mouse inflammatory cytokines and receptors (#PAMM-011D). qPCR array gene expression profiling. This experiment ex...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43681 | biostudies-arrayexpress
TranscriptomicsmiRNA 135b regulation by Il1r1 during inflammation
RT-PCR analysis of inflammatory cytokines and receptors following Il1alpha treatment of pEGP-miR-135b over-expressing cells compard to controls (pEGP-miR-null) using pathway-specific PCR arrays for the evaluation of mouse inflammatory cytokines and receptors (#PAMM-011D). qPCR array gene expression ...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43683 | biostudies-arrayexpress
TranscriptomicsGenetic toxicology and toxicogenomic analysis of 3 cigarette smoke condensates in vitro reveals few differences between high and low tar brands
This experiment investigated the response of mouse pulmonary epithelial cells in culture (FE1 cell line) to 3 different brands of cigarette smoke condensate. The three brands represent a full flavour, regular and king-size light cigarettes. These vary in some key chemical consistuents. Brand #1 has ...
ORGANISM(S): Mus musculus 
2012-04-01 | E-GEOD-30079 | biostudies-arrayexpress
TranscriptomicsCharacterization of Directly Regulated Thyroid Hormone Mediated Gene Expression Following Short-Term Perturbations in Thyroid Hormone Levels in Juvenile Mice
We investigated the effects of thyroid hormone disruptions on gene expression in juvenile mice liver to develop a stronger understanding of the mechanisms by which thyroid disrupting chemicals impair development. Gene expression was examined by hybridization of hepatic RNA to Agilent mouse microarr...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-21307 | biostudies-arrayexpress
TranscriptomicsSub-chronic forestomach transcriptional response in adult male MutaTMMouse following oral exposure to benzo(a)pyrene
Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male MutaTMMouse were exposed to three doses of benzo(a)pyrene or vehicle cont...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-43438 | biostudies-arrayexpress
TranscriptomicsExposure to Propylthiouracil in Pregnant Mice Potentiates the Transcriptional Response to Thyroid Hormone in the Fetal Cerebral Cortex
Although the effects of thyroid hormones (TH) on the brain development have been extensively studied perinatally, effects of TH of maternal origin on the fetal brain development have been largely unexplored. We applied a high throughput study on the mouse models with aberrant TH levels on gestation ...
ORGANISM(S): Mus musculus 
2014-02-04 | E-GEOD-43927 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression in C57BL/6 mice intratracheally instilled with Printex 90 carbon black nanoparticles
We investigated hepatic mRNA profiles of female mice exposed to 0.162 mg Printex 90 carbon black nanoparticles by single intra-tracheal instillation. We examined responses to this dose 1, 3 and 28 days after exposure, alongside respective controls. We show that genes part of the 3-hydroxy-3-methyl-g...
ORGANISM(S): Mus musculus 
2012-04-12 | E-GEOD-35192 | biostudies-arrayexpress
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