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TranscriptomicsTranscriptomic Assay of CD8 2012-05-15
In this study, Genome-wide transcriptomes of CD8+ T cells from HCV/HIV co-infected or mono-infected treatment-naive individuals were analyzed by using microarray assays. Pairwise comparisons were performed and differentially expressed genes were identified followed by quantitative real time PCR (qRT...
ORGANISM(S): Homo sapiens 
2012-05-17 | E-MEXP-3635 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of CD4 T cells in treatment-naive HIV
In this study, treatment-naive HIV, HCV mono-/co-infected individuals with CD4+ T cell counts >300/?l were recruited and their global gene expression profiles were investigated. By gene set enrichment analysis (GSEA), we revealed that gene sets of cell cycle progression, innate immune response and s...
ORGANISM(S): Homo sapiens 
2012-07-01 | E-MEXP-3601 | biostudies-arrayexpress
UnknownSource Apportionment and Influencing Factor Analysis of Residential Indoor PM2.5 in Beijing.
Not available
S-EPMC5923728 | biostudies-literature
TranscriptomicsTranscriptomic analysis of CD4 T cells
Treatment-naive HIV, HCV mono-/co-infected individuals with CD4+ T cell counts >300/uL were recruited, and the global gene expression profiles of CD4+ T cells were analyzed.Equal amount of CD4+ T cells isolated from each individual were pooled to form three replicative groups. Total RNA was isolated...
ORGANISM(S): Homo sapiens 
2012-04-28 | E-MTAB-1014 | biostudies-arrayexpress
TranscriptomicsResponsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity (2 of 2)
BACKGROUND: In addition to determining static states of gene expression (high vs. low), it is important to characterize their dynamic status. For example, genes with H3K27me3 chromatin marks are not only suppressed but also poised for activation. However, the responsiveness of genes to perturbations...
ORGANISM(S): Mus musculus 
2011-02-11 | E-GEOD-19814 | biostudies-arrayexpress
TranscriptomicsResponsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity (1 of 2)
BACKGROUND: In addition to determining static states of gene expression (high vs. low), it is important to characterize their dynamic status. For example, genes with H3K27me3 chromatin marks are not only suppressed but also poised for activation. However, the responsiveness of genes to perturbations...
ORGANISM(S): Mus musculus 
2011-02-11 | E-GEOD-19806 | biostudies-arrayexpress
TranscriptomicsTimed induction of 50 transcription factors in ES cells reveals a common mechanism to initiate differentiations
To decipher the structure and behaviors of the transcription factor (TF) network, we created 50 permanent mouse ES cell lines, in each of which one of the 50 transcription factors tagged with FLAG, is inserted into the doxycycline (dox)-repressible ROSA26 locus. Expression profiling reveals Cdx2 as ...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-14559 | biostudies-arrayexpress
TranscriptomicsPrincipal components of embryonic stem cell pluripotency
To decipher gene regulatory networks, we used systematic suppression of 97 transcription factors (TFs) and 7 other genes with shRNA in mouse embryonic stem (ES) cells, followed by global gene expression profiling. Meta-analysis of these data together with the earlier data obtained by the induction o...
ORGANISM(S): Mus musculus 
2013-03-14 | E-GEOD-26520 | biostudies-arrayexpress
TranscriptomicsDe Novo Transcriptomic Analysis of a High Lipid-producing Mutant in the Green Alga Dunaliella tertiolecta through RNA-Seq
Background: For many years, increasing demands for fossil fuels have met with limited supply. As a potential substitute and renewable source of biofuel feedstock, microalgae have received significant attention. However, few of the current algal species produce high lipid yields to be commercially vi...
ORGANISM(S): Dunaliella tertiolecta 
2015-07-23 | E-GEOD-70876 | biostudies-arrayexpress
ProteomicsRetinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina
Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the loss of the retinal pigment epithelium (RPE) and photoreceptors and/or retinal and choroidal angiogenesis. Here we use AMD patient specific RPE cells with the Y402H high-risk polymorphism in the comp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-21 | MSV000088713 | MassIVE
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