Heat shock proteins are responsible for protein folding in cells. HSP90 is one of the most important chaperones in human cells, and inhibiting HSP90 is a potential strategy for cancer therapy. Multiple HSP90 inhibitors have been in clinical trials. However, none of them has been approved for disease...
Using cysteine footprinting to globally profile protein structure changes. The method was further applied to study the unfolding effect of tunicamycin.
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast)
Manipulating protein synthesis is commonly applied in bio-related research to uncover protein functions and cellular activities. Multiple inhibitors with distinct mechanisms are widely used, but it is extraordinarily challenging to systematically determine and evaluate their inhibition efficiencies,...
