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MetabolomicsCombined analysis of cecal microbiota and metabolomics reveals the intervention mechanism of Dayuan Yin in acute lung injury

The ancient Chinese medicinal formula, Dayuan Yin (DYY), has a long history of use in treating respiratory ailments and shown to be effective in treating acute infectious diseases. This study aims to explore how DYY may impact intestinal flora and metabolites induced by acute lung injury (ALI). A...

2024-09-20 | MTBLS10741 | MetaboLights
MetabolomicsSpirulina Prevents Hepatic Steatosis by Promoting Macrophage M2 Polarization via Gut Microbiota-Derived 2-Hydroxy-3-Methylbutyrate
Background & Aims: Spirulina, a microalgae renowned for its nutrient density, shows promise in modulating glucose and lipid metabolism. However, its efficacy and underlying mechanisms against metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. We hypothesized that spirul...
2026-06-30 | MTBLS14901 | MetaboLights
MetabolomicsSpirulina Prevents Hepatic Steatosis by Promoting Macrophage M2 Polarization via Gut Microbiota-Derived 2-Hydroxy-3-Methylbutyrate
Background & Aims: Spirulina, a microalgae renowned for its nutrient density, shows promise in modulating glucose and lipid metabolism. However, its efficacy and underlying mechanisms against metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. We hypothesized that spirul...
2026-06-30 | MTBLS14903 | MetaboLights
GenomicsYy1 activity in mouse embryonic stem cells
This SuperSeries is composed of the following subset Series: GSE31784: Expression changes in Yy1 knock down mouse embryonic stem cells GSE31785: Yy1 occupancy of mouse ES cell genome Refer to individual Series
ORGANISM(S): Mus musculus 
2012-01-04 | E-GEOD-31786 | biostudies-arrayexpress
TranscriptomicsExpression changes in Yy1 knock down mouse embryonic stem cells
We have determined the global gene expression upon loss of function of the Yy1 transcription factor in mouse embryonic stem cells Total RNA was extracted from ES cells transiently transfected with yy1-specific or scrampled-control siRNA oligos 48 hr post-transfection.
ORGANISM(S): Mus musculus 
2012-01-04 | E-GEOD-31784 | biostudies-arrayexpress
ProteomicsCalcineurin-regulated Phosphopeptide(30 min) and CaN-regulated dephosphopeptide(10 min) researchs in Pheromone gland of  Helicoverpa armigera
Calcineurin-regulated Phosphopeptide(30 min) and CaN-regulated dephosphopeptide(10 min) researchs used Itraq method in Pheromone gland of Helicoverpa armigera
ORGANISM(S): Helicoverpa armigera (Cotton bollworm) 
2017-10-10 | PXD006380 | Pride
Proteomics Helicoverpa armigera Pheromone gland (de)phosphopeptides Itraq 
ProteomicsDynamic Yin-Yang regulation network of O-GlcNAcylation and phosphorylation mediates vernalization response for flowering in winter wheat
Protein post-translational modification (PTM) increases the functional diversity of the proteome and regulates numerous biological processes in eukaryotes. Two types of PTMs, O-linked-acetyl glucosamine modification (O-GlcNAc) and phosphorylation have been identified on the same amino acid, are cons...
ORGANISM(S): Triticum aestivum (Wheat) 
2020-12-18 | PXD008285 | Pride
Proteomics O-glcnacylation modification Phosphorylation modification 
ProteomicsDynamic Yin-Yang regulation network of O-GlcNAcylation and phosphorylation mediatesvernalization response for flowering in winter wheat, part 2
Protein post-translational modification (PTM) increases the functional diversity of the proteome and regulates numerous biological processes in eukaryotes. Two types of PTMs, O-linked-acetyl glucosamine modification (O-GlcNAc) and phosphorylation have been identified on the same amino acid, are cons...
ORGANISM(S): Triticum aestivum (Wheat) 
2021-05-18 | PXD008298 | Pride
Proteomics O-glcnacylation modification Phosphorylation modification 
TranscriptomicsTranscription profiling of fission yeast with deletion or overexpression of ste11 and changes in gene expression after nitrogen starvation of h plus, h minus, h90fus1 and h90ste11 cells to investigate control of gene expression during early sexual differentiation
Fission yeast cells belong to one of two specialized cell types, M or P. Specific environmental conditions trigger sexual differentiation, which leads to an internal program starting with pheromone signalling between M and P cells, followed by mating, meiosis and sporulation. The initial steps of ...
ORGANISM(S): Schizosaccharomyces pombe 
2006-09-22 | E-TABM-139 | biostudies-arrayexpress
TranscriptomicsS. cerevisiae cells: control vs positive supercoiling accumulation in absence of telomere silencing after 0 and 120 min
Positive DNA helical stress accumulates in vivo by the unbalanced relaxation of positive and negative DNA supercoils in M-NM-^Ttop1, top2ts, pGPD:TopA yeast cells. The resulting overwinding of DNA greatly diminishes overall RNA synthesis. Here we show that whereas most genes reduce their transcript ...
ORGANISM(S): Saccharomyces cerevisiae 
2009-12-01 | E-GEOD-18241 | biostudies-arrayexpress
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