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ProteomicsDYRK1A regulates B cell class switch recombination through phosphorylation of MSH6
Effective protection from viral infections depends on the antibody-specific isotype. Here, we found that the protein kinase, DYRK1A, is essential for B cell-mediated protection from viral infection and vaccination through regulation of class switch recombination (CSR). Dyrk1a-deficient B cells were ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-16 | PXD034156 | Pride
Antibody Clonal selection B cell Class-switch recombination Humoral immunity 
TranscriptomicsTranscription profiling of Plasmodium 3D7AH1S2 and 3D7S8.4 at three different stages of intraerythrocytic cycle: ring, trophozite and schizont stage
Comparison of expression profile of two 3D7 isogenic clones : 3D7AH1S2 and 3D7S8.4 at three different stages of intraerythrocytic cycle: ring, trophozite and schizont stage
ORGANISM(S): Plasmodium falciparum 
2004-06-15 | E-MEXP-128 | biostudies-arrayexpress
UnknownA genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits.
Not available
S-EPMC3286457 | biostudies-literature
UnknownLongitudinal Peripheral Blood Transcriptomics Reveal Novel Signatures During Cardiac Allograft Rejection.
Not available
S-EPMC12818864 | biostudies-literature
TranscriptomicsRNA sequencing of bone marrow CD34+ cells from myelodysplastic syndrome patients with and without SF3B1 mutation and from healthy controls
The splicing factor SF3B1 is the most commonly mutated gene in the myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ring sideroblasts (RARS). MDS is a disorder of the hematopoietic stem cell and we thus studied the transcriptome of CD34+ cells from MDS patients w...
ORGANISM(S): Homo sapiens 
2014-11-22 | E-GEOD-63569 | biostudies-arrayexpress
UnknownDisruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells.
Not available
S-EPMC4430703 | biostudies-literature
UnknownComparative analysis of the transcriptome across distant species.
Not available
S-EPMC4155737 | biostudies-literature
UnknownFunctional Assessment for Surgery by a Timed Walk (FAST Walk) study: protocol for a multicentre prospective cohort study of the 6 min walk test for preoperative risk stratification in major non-cardiac surgery.
Not available
S-EPMC12778347 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
UnknownCombination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial.
Not available
S-EPMC7068822 | biostudies-literature
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