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TranscriptomicsExpression data comparing human DKK1 and control vector transfected murine osteochondrosarcoma cells (MOS-J)
Canonical Wnt signaling controls proliferation and differentiation of osteogenic progenitor cells, and tumor-derived secretion of the Wnt antagonist Dickkopf-1 (Dkk1) is correlated with osteolyses and metastasis in many bone malignancies. However, the role of Dkk1 in the oncogenesis of primary osteo...
ORGANISM(S): Mus musculus 
2012-12-22 | E-GEOD-43112 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MSCs during expansion
Human mesenchymal stem cells or multipotent stromal cells (MSCs) are of interest for clinical therapy, in part because of their capacity for proliferation and differentiation. However, results from clinical trials and in vitro models have been variable, possibly due to MSC heterogeneity and a lack ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9520 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human multipotent stromal cells in single-cell-derived colonies to investigate commitment to differentiation
Human multipotent stromal cells readily form single-cell-derived colonies when plated at clonal densities. However, the colonies are heterogeneous because cells from a colony form new colonies that vary in size and differentiation potential when replated at clonal densities. The experiments here tes...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-13002 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human passage 1 mesenchymal stem cells from bone marrow stroma during 15 day culturing
To study the gene expression changes in mesenchymal stem cells from bone marrow stroma (MSCs) during in vitro expansion (from low density), passage 1 MSC were grown in culture for 15 days with medium change every 2-3 days. Samples for microarrays were taken at day 5 (early log-phase), 10 (late log-p...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12800 | biostudies-arrayexpress
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