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ProteomicsFaecal Proteases and Immune Signatures Drive Subtype-Specific Enteric Neuronal Activation in IBS
Background: Luminal proteases have been implicated in epithelial barrier dysfunction and visceral hypersensitivity in irritable bowel syndrome (IBS), yet their impact on the enteric nervous system (ENS), the principal regulator of gastrointestinal function, remains unknown. We investigated whether ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD071836 | Pride
Protease-activated receptors (pars) Irritable bowel syndrome Serine and cysteine protease activity Faecal supernatant proteomics Luminal–neuronal signalling axis 
ProteomicsMouse stool samples in response to antibiotic treatment
Background and Objectives: Antibiotic (ABx) therapy is associated with an increased risk for Crohn´s Disease but the underlying mechanisms are unknown. We observed high fecal serine protease activity (PA) to be a frequent side effect of ABx therapy in patients. The aim of the present study was to un...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-11 | PXD007914 | Pride
Mouse Antibiotic treatment Velos Intestinal barrier Stool Protease activity 
UnknownCost-Effectiveness of Treatments after Closed Extraarticular Distal Radius Fractures in Older Adults from the WRIST Clinical Trial.
Not available
S-EPMC7855198 | biostudies-literature
TranscriptomicsRNA sequencing of allelic series of miR-17~92 mutant embryos.
We report the generation of an allelic series of miR-17~92 mutant mice, each carrying the targeted deletion of specific miRNA families encoded by the cluster. We integrate the phenotypic characterization of these strains with RNA-seq analysis showing the consequences of selective miRNA inactivation ...
ORGANISM(S): Mus musculus 
2015-02-02 | E-GEOD-63813 | biostudies-arrayexpress
TranscriptomicsAnalysis of exosome RNA from co-culture of cancer cell and stroma cell
How stroma communicates with cancer to influence treatment response is poorly understood. We show that stromal fibroblasts protect breast cancer (BrCa) against radiation and chemotherapy through an exosome-mediated anti-viral pathway and NOTCH3. Stroma increases RAB27B and transfers exosomes to BrCa...
ORGANISM(S): Homo sapiens 
2014-10-24 | E-GEOD-60997 | biostudies-arrayexpress
GenomicsMedulloblastoma expression profiling (mbt)
Medulloblastoma expression profiling
EGAD00010001300 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-07-04-2017-10:40:02:500-10 - samples
RNA sequencing data for 170 medulloblastoma tumor samples
EGAD00001003279 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-03-01-2017-12:51:29:816-785 - samples
WGS data of medulloblastoma tumor/control pairs.
EGAD00001003127 | EGA
GenomicsSTJUDE_450k
Medulloblastoma methylation profiling
EGAD00010001319 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-03-01-2017-12:19:28:146-782 - samples
WGS data of medulloblastoma tumor/control pairs.
EGAD00001003126 | EGA
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