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TranscriptomicsImmune-activation as a therapeutic direction for patients with high-risk ovarian cancer based on gene expression signature (2)
Advanced-stage ovarian cancer is one of the most lethal gynecologic malignancies. To improve prognosis of patients with ovarian cancers, a predictive biomarkers leading to personalized treatments are required. In this large-scale cross-platform study of six microarray datasets consisting of 1054 ova...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-32063 | biostudies-arrayexpress
TranscriptomicsImmune-activation as a therapeutic direction for patients with high-risk ovarian cancer based on gene expression signature (1)
The Japanese Serous Ovarian Cancer Study Group Advanced-stage ovarian cancer is one of the most lethal gynecologic malignancies. To improve prognosis of patients with ovarian cancers, a predictive biomarkers leading to personalized treatments are required. In this large-scale cross-platform study of...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-32062 | biostudies-arrayexpress
GenomicsSearching for variants associated with endometriosis
We explored regulatory mechanism of a SNP on chromosome 9p21 associated with endometriosis by leveraging “allele-specific” functional genomic approaches. By re-sequencing 1.29 Mb of 9p21 region and scrutinizing DNase-seq data from the ENCODE project, we prioritized rs17761446 as a candidate function...
EGAS00001001741 | EGA
TranscriptomicsGene expression profiles of serous ovarian cancer samples
To elucidate the mechanisms of rapid progression of serous ovarian cancer, gene expression profiles from forty-three ovarian cancer tissues comprising eight early stage and thirty-five advanced stage tissues were performed using oligonucleotide microarrays of 18,716 genes. By non-negative matrix fac...
ORGANISM(S): Homo sapiens 
2009-07-19 | E-GEOD-12470 | biostudies-arrayexpress
Genomicsena-DATASET-NIG-07-03-2016-14:49:59:413-12 - samples
We performed target re-sequencing for 1.29 Mb interval of chromosome 9 (chr9:21299764–22590271, hg19). NimbleGen SeqCap EZ choice system was used as a target enrichment method (Roche Diagnostics). A DNA probe set complementary to the target region was designed by NimbleDesign. The libraries were seq...
EGAD00001001942 | EGA
GenomicsData Access Committee of National Institute of Genetics of Japan
Data Access Committee EGAC00001000448
EGAC00001000448 | EGA
GenomicsLoss of histone demethylase JARID1C triggers genomic instability in cancer.
Chromatin remodelers are recurrently mutated in cancer. Among these, JARID1C, (KDM5C) a histone demethylase, is frequently inactivated in clear cell renal cell carcinoma (ccRCC) patients. How the genetic inactivation of JARID1C leads to cancer remains largely unknown. Here we report that JARID1C bin...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-73267 | biostudies-arrayexpress
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