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MetabolomicsMulti‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effe...
2019-02-28 | MTBLS794 | MetaboLights
TranscriptomicsInnate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes
We report the profiling of induced mRNA transcripts in two C. elegan replicate populations -- WT (N2) and mutant strain with deficient HLH30. Both strains were fed either OP50 strain of e-coli (normal feed) or S. aureus Examination of infected versus uninfected wildtype and mutant lawns of animals
ORGANISM(S): Caenorhabditis elegans 
2015-06-04 | E-GEOD-57739 | biostudies-arrayexpress
ProteomicsSmall intestinal submucosa-derived extracellular matrix as heterotopic scaffold for cardiovascular applications
Structural cardiac lesions are often surgically repaired using prosthetic patches, which can be of biological or synthetic nature. In the current clinical scenario, amongst biological patches, are gaining very much interest those derived from decellularization of xenogeneic scaffold. These patches m...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-03-11 | PXD038206 | Pride
Cardiac repair Cardiac surgery Tergitol Extracellular matrix (ecm) Triton x 100 Small intestinal submucosa (sis) Decellularization 
UnknownLeft Ventricular Myocardial Noncompaction with Advanced Atrioventricular Conduction Disorder and Ventricular Arrhythmias in a Young Patient: Role of MIB1 Gene.
Not available
S-EPMC8468736 | biostudies-literature
UnknownStudy protocol for a pragmatic randomised multiple baseline trial evaluating Knowledge Insight Tools (KIT), a cognitive behavioural therapy-informed school-based counselling intervention for children and young people in UK secondary schools with low mood and anxiety.
Not available
S-EPMC11440936 | biostudies-literature
UnknownWhy do young men not seek help for affective mental health issues? A systematic review of perceived barriers and facilitators among adolescent boys and young men.
Not available
S-EPMC11868194 | biostudies-literature
UnknownProtecting our future generation: study protocol for a randomized controlled trial evaluating a sexual health self-care intervention with Native American youth and young adults.
Not available
S-EPMC6888928 | biostudies-literature
TranscriptomicsRNA-seq of human intestinal organoids infected with Salmonella enterica at 2.5h and 8h post infection
The purpose of this experiment was to identify intestinal epithelial responses to various strains of Salmonella enterica. Human intestinal organoids were infected with three serovars of Salmonella; Typhimurium, Enteritidis and Typhi, as well as type 3 secretion system -1 and -2 mutants in Typhimuriu...
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-10451 | biostudies-arrayexpress
MetabolomicsUmbilical cord blood metabolome differs in relation to delivery mode, birth order and sex, maternal diet and possibly future allergy development in rural children
Allergy is one of the most common diseases among young children yet all factors that affect development of allergy remain unclear. In a small cohort of 65 children living in the same rural area of south-west Sweden, we have previously found that maternal factors, including prenatal diet, affect chil...
2020-12-18 | MTBLS2017 | MetaboLights
UnknownA community-based intervention (Young SMILES) to improve the health-related quality of life of children and young people of parents with serious mental illness: randomised feasibility protocol.
Not available
S-EPMC6186077 | biostudies-literature
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