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UnknownAging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia.
Aging is associated with diminished muscle mass, reductions in muscle stem cell functions, and increased muscle fibrosis. The immune system, especially macrophages, can have important roles in modulating muscle growth and regeneration, suggesting that the immune system may also have significant infl...
S-EPMC6355087 | biostudies-literature
UnknownCannabis Use Frequency and Cannabis-Related Consequences in High-Risk Young Adults Across Cannabis Legalization.

Importance

A key concern about recreational cannabis legalization is increases in use and adverse consequences, particularly among young adults (aged 18-29 years) who have the highest prevalence of cannabis use, and especially in higher-risk, more vulnerable young adults. However, few longit...
S-EPMC10534274 | biostudies-literature
UnknownEarly postnatal nutrition after preterm birth and cardiometabolic risk factors in young adulthood.

Objectives

Adults born preterm at very low birthweight (VLBW; <1500 g) have a non-optimal cardiometabolic risk factor profile. Since higher protein intake during the first weeks of life predicted a healthier body composition in adulthood in our previous studies, we hypothesized that it would...
S-EPMC6310277 | biostudies-literature
UnknownEpigenetic signature of very low birth weight in young adult life.

Background

Globally, one in ten babies is born preterm (<37 weeks), and 1-2% preterm at very low birth weight (VLBW, <1500 g). As adults, they are at increased risk for a plethora of health conditions, e.g., cardiometabolic disease, which may partly be mediated by epigenetic regulation. We c...
S-EPMC11798856 | biostudies-literature
UnknownTranscriptome kinetics of circulating neutrophils during human experimental endotoxemia.
Polymorphonuclear cells (neutrophils) play an important role in the systemic inflammatory response syndrome and the development of sepsis. These cells are essential for the defense against microorganisms, but may also cause tissue damage. Therefore, neutrophil numbers and activity are considered to ...
S-EPMC3367952 | biostudies-literature
UnknownNeonatal Nutrition Predicts Energy Balance in Young Adults Born Preterm at Very Low Birth Weight.
Epidemiological studies and animal models suggest that early postnatal nutrition and growth can influence adult health. However, few human studies have objective recordings of early nutrient intake. We studied whether nutrient intake and growth during the first 9 weeks after preterm birth with very ...
S-EPMC5748733 | biostudies-literature
UnknownBehavioral economics indices predict alcohol use and consequences in young men at 4-year follow-up.

Background and aims

The alcohol purchase task (APT), which presents a scenario and asks participants how many drinks they would purchase and consume at different prices, generates indices of alcohol reward value that have shown robust associations with alcohol-related outcomes in numerous st...
S-EPMC9796857 | biostudies-literature
UnknownPulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers.

Rationale

Waterpipes, also called hookahs, are currently used by millions of people worldwide. Despite the increasing use of waterpipe smoking, there is limited data on the health effects of waterpipe smoking and there are no federal regulations regarding its use.

Objectives

To assess...
S-EPMC5027211 | biostudies-literature
UnknownLong-term prognosis of young breast cancer patients (≤40 years) who did not receive adjuvant systemic treatment: protocol for the PARADIGM initiative cohort study.

Introduction

Currently used tools for breast cancer prognostication and prediction may not adequately reflect a young patient's prognosis or likely treatment benefit because they were not adequately validated in young patients. Since breast cancers diagnosed at a young age are considered pro...
S-EPMC5695414 | biostudies-literature
UnknownRecommendations for the surveillance of mental health problems in childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group.
Survivors of childhood, adolescent, and young adult (diagnosed when <25 years of age) cancer are at risk of mental health problems. The aim of this clinical practice guideline is to harmonise international recommendations for mental health surveillance in survivors of childhood, adolescent, and youn...
S-EPMC9639707 | biostudies-literature
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