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MetabolomicsUntargeted gas chromatography–mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat
Polycystic kidney disease (PKD) encompasses a spectrum of inherited disorders that lead to end-stage renal disease (ESRD). There is no cure for PKD and current treatment options are limited to renal replacement therapy and transplantation. A better understanding of the pathobiology of PKD is needed ...
2023-01-26 | MTBLS748 | MetaboLights
TranscriptomicsInfectious Bursal Disease Virus (IBDV) Infection
Infectious bursal disease virus (IBDV) is a highly contagious dsRNA virus (Birnaviridae) which causes immuno-suppression in chickens. Although largely controlled by vaccination, new, virulent strains of the virus mean that infectious bursal disease (IBD or ëGumboroí disease) still remains a threat t...
ORGANISM(S): Gallus gallus 
2014-12-30 | E-TABM-1129 | biostudies-arrayexpress
GenomicsGenome wide association study on coronary heart disease in patients with familial hypercholesterolemia
Mutations in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a disorder characterized by coronary heart disease (CHD) at young age. We aimed to apply an extreme sampling method to enhance the statistical power to identify novel genetic risk variants for CHD...
EGAS00001000734 | EGA
TranscriptomicsTranscription profiling of expressed human chromosome 21 genes in transchromosomic mouse embryos carrying a freely segregating copy of Hsa21
Detection of expressed human chromosome 21 genes in transchromosomic mouse embryos carrying a freely segregating copy of Hsa21.
ORGANISM(S): Mus musculus 
2005-11-19 | E-MEXP-409 | biostudies-arrayexpress
TranscriptomicsConcerted involvement of Cdx/Hox genes and Wnt signalling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.
Decrease in Cdx dosage in an allelic series of mouse Cdx mutants leads to progressively more severe posterior vertebral defects. These defects are corrected by posterior gain of function of the Wnt effector Lef1. Precocious expression of Hox paralogous 13 genes also induces vertebral axis truncat...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-30113 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E2F4 double knockout mice and heterozygous littermates
We considered the possibility that removal of E2F4, as a key regulator of cellular quiescence, would cause systemic perturbations in the expression of E2F4 bound genes involved in cell cycle and proliferation. To test whether these pertubrations were reflected in the adult tissues' gene expression p...
ORGANISM(S): Mus musculus 
2007-06-14 | E-MEXP-1131 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation and RNA-seq analysis in purified quiescent yeast cells to identify the genomic RNA polymerase II and histone H3 methylation occupancy profiles and the quiescent cell transcriptome.
A defining characteristic of quiescent cells is their low level of gene activity compared to growing cells. Using a yeast model for cellular quiescence, we compared the genome-wide profiles of multiple histone modifications between growing and quiescent cells, and correlated these profiles with the...
ORGANISM(S): Saccharomyces cerevisiae 
2016-09-01 | E-GEOD-72650 | biostudies-arrayexpress
GenomicsFH+Controls - samples
Gencode control samples using 550K
EGAD00010000580 | EGA
GenomicsFH+CAD - samples
Gencode case samples using 550K
EGAD00010000578 | EGA
GenomicsErasmus MC - ARGOS study Data Access Committee
Data Access Committee EGAC00001000182
EGAC00001000182 | EGA
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