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TranscriptomicsImpact of aging on cell-to-cell transcriptional variability during immune stimulation
We explored how aging impacts transcriptional dynamics using single-cell RNA-sequencing to profile hundreds of CD4+ T cells from young and old mice from two divergent species. In young animals, immunological challenge drives a conserved transcriptomic switch from highly variable to tightly regulated...
ORGANISM(S): Mus musculus 
2016-07-21 | E-MTAB-4888 | biostudies-arrayexpress
ProteomicsHypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics
Hypoxic exposure during development can have a profound influence on offspring physiology, including cardiac dysfunction, yet many reptile embryos naturally experience periods of hypoxia in buried nests. American alligators experimentally exposed to developmental hypoxia demonstrate morphological an...
ORGANISM(S): Alligator Mississippiensis (ncbitaxon:8496) 
2019-05-22 | MSV000083838 | MassIVE
TranscriptomicsGlobal gene expression in response to SARS mouse adapted variants MA-15, MA-15epsilon, and MA-15-gamma in young and aged mice
Purpose of this experiment was to study the host-transcriptional response to MA-15, MA-15epsilon, and MA-15-gamma in both young and aged mice to further understand the differences between response within each age group, and the age-related differences in response to each virus. Young (8 weeks old) a...
ORGANISM(S): Mus musculus 
2014-06-02 | E-GEOD-36969 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [scRNA-seq]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2026-07-12 | E-MTAB-17228 | biostudies-arrayexpress
TranscriptomicsAMPK agonist AICAR improves cognition and motor coordination in young and aged mice
Normal aging can result in a decline of memory and muscle function. Exercise may prevent or delay these changes. However, aging associated frailty may preclude physical activity. AMP-activated protein kinase (AMPK) is a transcriptional regulator important for muscle physiology. In the present study...
ORGANISM(S): Mus musculus 
2014-01-17 | E-GEOD-50873 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [Micro-C]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15688 | biostudies-arrayexpress
UnknownReal-world outcomes for young adult patients receiving CD19 CAR T-cell therapy.
Not available
S-EPMC12166372 | biostudies-literature
TranscriptomicsSingle-cell and single-nucleus RNAseq of the human and mouse skeletal muscle across age
This study aims to characterize the diversity of cell types in human skeletal muscle across age using two complementary technologies: single-cell and single-nucleus sequencing, which provide a comprehensive coverage of cell types in the muscle. We leveraged the aforementioned datasets to study chang...
ORGANISM(S): Mus musculus 
2024-03-07 | E-MTAB-13874 | biostudies-arrayexpress
Transcriptomicspreparative changes in rat intestine and lung for birth
To identify genes important in fetal preparation for birth. Transcript profiling using microarray analysis was performed using lung and intestine RNA from a single animal from each of 10 litters at a given gestational age. Array experiments were performed by the Genomics CoreLab, Cambridge Comprehen...
ORGANISM(S): Rattus norvegicus 
2010-11-21 | E-GEOD-16849 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the liver in 15-day-old C3H/HeJ mice
Male C3H/HeOuJ mice are susceptible to spontaneous liver neoplasms. We collected liver samples from young, tumour-free mice for control experiments. Liver tissue samples were snap frozen in liquid nitrogen and total RNA was extracted using the AllPrep 96 DNA/RNA Kit (Qiagen) according to the manufac...
ORGANISM(S): Mus musculus 
2018-07-29 | E-MTAB-6972 | biostudies-arrayexpress
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