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UnknownIntermittent Theta Burst Stimulation (iTBS) as an Optimal Treatment for Schizophrenia Risk Decision: an ERSP Study.
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S-EPMC8143028 | biostudies-literature
Transcriptomicswenyan
Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy with unknown etiology. The disease mostly occurs in children between the ages of 3 and 13 in a diagonal belt-like area ranging from Northeast to Southwest China. We carried out this microarray analysis to investigate the differenc...
ORGANISM(S): Homo sapiens 
2014-08-30 | E-MTAB-2494 | biostudies-arrayexpress
TranscriptomicsOptimized siRNAs with a minimal off-target effect facilitate the screening of essential genes in cancer cells
siRNAs with dN are a promising and easy approach to characterize essential genes by minimizing the off-target effect in cancer cells. mRNA profiles of HCT 116 cells after the transfection of siRNAs or blank control by deep sequencing, using HiSeq 2000
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-62968 | biostudies-arrayexpress
ProteomicsSalivary Proteomics Research Related to Obstructive Sleep Apnea
The research direction of this project is to analyze the salivary proteome of patients with obstructive sleep apnea.
ORGANISM(S): Homo Sapiens 
2025-04-01 | PXD062443 |
ProteomicsProteome and Ubiquitylome Analyses of Maize Endoplasmic Reticulum Under Heat Stress
High temperatures severely affect plant growth and pose a threat to global crop production. Heat causes the accumulation of misfolded proteins in the ER, and triggers the heat shock response (HSR) in the cytosol and the unfolded protein response (UPR) in the ER. Excessive misfolded proteins undergo ...
ORGANISM(S): Zea Mays 
2023-07-24 | PXD044013 |
ProteomicsLow-dose metformin targets the lysosome-AMPK pathway through PEN2
Metformin is the most prescribed anti-diabetic medicine, and has also been shown to have other various benefits, such as anti-aging and anti-cancer effects. For clinical doses of metformin, it is known that AMPK plays a major role; however, the direct molecular target of metformin remains unclear. H...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-01 | PXD030090 |
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-09-16 | PXD056134 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
ProteomicsProteomics and Human Microchips Identify Thrombospondin-1 as a Potential Biomarker for Calciphylaxis Stem Cell Therapy
Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare disease with high mortality rate. We effectively rescued CUA patients with novel human amnion-derived mesenchymal stem cell (hAMSC) therapy. Due to the heterogeneity of cutaneous lesion, it is imperative to identify non-inv...
ORGANISM(S): Homo Sapiens 
2026-05-14 | PXD078388 |
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