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ProteomicsTMT proteomic analysis of milk of Guanzhong dairy goat
Tandem mass tagging (TMT) was employed in this study to explore the differential proteome of milk from Guanzhong dairy goats.These bioinformatics investigations will provide new insights into the physiological activities of proteins in goat milk from Guanzhong dairy goats, as well as a scientific fo...
ORGANISM(S): Anaplasma Sp. Goat50/1 Anaplasma Sp. Goatc/1 
2023-12-11 | PXD047737 |
ProteomicsSmall intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning
Sepsis is a severe global health issue with high mortality rates, and sepsis-associated encephalopathy (SAE) further exacerbates this risk. While recent studies have shown the migration of gut immune cells to the lungs after sepsis, their impact on the central nervous system remains unclear. Our res...
ORGANISM(S): Mus Musculus 
2024-10-28 | PXD057241 |
ProteomicsLow-dose metformin targets the lysosome-AMPK pathway through PEN2
Metformin is the most prescribed anti-diabetic medicine, and has also been shown to have other various benefits, such as anti-aging and anti-cancer effects. For clinical doses of metformin, it is known that AMPK plays a major role; however, the direct molecular target of metformin remains unclear. H...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-01 | PXD030090 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD056134 |
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