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ProteomicsESRRB Facilitates the Conversion of Trophoblast-like Stem Cells from Induced Pluripotent Stem cells by Directly Regulating KRT8 and CDX2
Porcine induced pluripotent stem cells (piPSCs) could serve as a great model system for human stem cell pre-clinical research. However, the pluripotency gene network of piPSCs, especially the function for the core transcription factor ESRRB, was poorly understood. Here, we constructed ESRRB-overexpr...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-02-17 | PXD027539 | Pride
Trophoblast stem cells (tscs) Esrrb Induced pluripotent stem cells (ipscs) Cdx2 Krt8 
UnknownGenomic variants of genes associated with three horticultural traits in apple revealed by genome re-sequencing.
Not available
S-EPMC4596325 | biostudies-literature
UnknownComparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study.
Not available
S-EPMC7173822 | biostudies-literature
UnknownMonocytes perturbation implicated in the association of stress hyperglycemia with postoperative poor prognosis in non-diabetic patients with Stanford type-A acute aortic dissection.
Not available
S-EPMC11520058 | biostudies-literature
UnknownNeoantigens and the tumor microenvironment play important roles in the prognosis of high-grade serous ovarian cancer.
Not available
S-EPMC8801100 | biostudies-literature
UnknownGenetic Alteration Profiles and Clinicopathological Associations in Atypical Parathyroid Adenoma.
Not available
S-EPMC7969847 | biostudies-literature
UnknownThe celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy.
Not available
S-EPMC7113887 | biostudies-literature
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014836 | Pride
Hela cell Irucaparib-tp3 Parp1 degradation 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-08-01 | PXD014838 | Pride
Primary neonatal rat cardiomyocyte Irucaparib Irucaparib-tp5 Parp1 degradation 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014839 | Pride
Rucaparib Hela cell Irucaparib Parp trapping Chromatin 
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