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ProteomicsIsobaric matching between runs and novel PSM-level normalization in MaxQuant strongly improve reporter ion-based quantification - mouse tissue dataset
Isobaric labeling has the promise of combining high sample multiplexing with precise quantification. However, normalization issues and the missing value problem of complete n-plexes hamper quantification across more than one n-plex. Here we applied two novel algorithms implemented in MaxQuant that s...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-22 | PXD019880 | Pride
Match between runs Normalization Tandem mass tag Isobaric labeling Multiplexed quantification 
ProteomicsIsobaric matching between runs and novel PSM-level normalization in MaxQuant strongly improve reporter ion-based quantification - Peli1 knock-out mice dataset
Isobaric labeling has the promise of combining high sample multiplexing with precise quantification. However, normalization issues and the missing value problem of complete n-plexes hamper quantification across more than one n-plex. Here we introduce two novel algorithms implemented in MaxQuant that...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-22 | PXD019881 | Pride
Match between runs Normalization Tandem mass tag Isobaric labeling Multiplexed quantification 
ProteomicsBenchmarking differential expression, imputation and quantification methods for proteomics data
Data analysis is a critical part of quantitative proteomics studies in interpreting biological questions. Numerous computational tools including protein quantification, imputation, and differential expression (DE) analysis were generated in the past decade. However, searching optimized tools is stil...
ORGANISM(S): Homo Sapiens (human) Saccharomyces Cerevisiae (baker's Yeast) Drosophila Melanogaster (fruit Fly) 
2022-11-16 | PXD029891 | JPOST Repository
ProteomicsQuantification Quality Control Emerges as A Crucial Factor to Enhance Single Cell Proteomics Data Analysis
Mass spectrometry (MS)-based single-cell proteomics (SCP) provides us the opportunity to unbiasedly explore biological variability within cells without the limitation of antibody availability. This field is rapidly developed with the main focuses on instrument advancement, sample preparation refinem...
ORGANISM(S): Homo Sapiens (human) 
2025-01-09 | PXD048595 | JPOST Repository
UnknownEpigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma.
Not available
S-EPMC10462855 | biostudies-literature
UnknownDe novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Not available
S-EPMC7007577 | biostudies-literature
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